妊娠中期孕妇血清中可溶性endoglin水平对重度子痫前期预测的探讨  

Prediction for severe preeclampsia with soluble endoglin in maternal serum in second-trimester

作　　者：唐亮芳[1] 陈倩[1] 廖秦平[1] 

机构地区：[1]北京大学第一医院妇产科,100034

出　　处：《中国妇产科临床杂志》2011年第3期206-208,共3页Chinese Journal of Clinical Obstetrics and Gynecology

基　　金：北京大学985工程基金(985-2-015-24)资助

摘　　要：目的探讨妊娠中期14～20周孕妇血清中可溶性endoglin(sEng)水平是否对重度子痫前期有预测价值。方法前瞻性留取2008年11月至2009年10月妊娠14～20周孕妇行唐氏筛查时的血清,追踪孕妇的妊娠结局,获取早发型重度子痫前期组14例,晚发型重度子痫前期组25例,正常对照组25例和早产组13例,用ELISA方法测定各组孕妇妊娠中期血清中sEng的浓度,数据表示为中位数(四分位数间距)形式。结果早发型重度子痫前期组、晚发型重度子痫前期组、正常对照组和早产组孕妇妊娠中期血清中的sEng浓度分别为0.440ng/ml(0.526ng/ml)、0.594ng/ml(0.457ng/ml)、0.483ng/ml(0.194ng/ml)、0.460ng/ml(0.204ng/ml)。各组孕妇血清中sEng浓度间差异无统计学意义(Chi-Square值=1.371,P=0.712)。结论妊娠中期14～20周孕妇血清中的sEng水平对重度子痫前期尚未显示出明显的预测价值。Objective To investigate the value of maternal serum level of soluble endoglin（sEng）in the second-trimester in predicting severe preeclampsia.Methods Maternal serum samples were obtained at 14 to 20 gestation weeks together with Down syndrome screening,all gravidas were followed up until delivery.14 early-onset severe preeclampsia and 25 late-onset severe preeclampsia were identified.Another 25 healthy pregnant women and 13 preterm mothers were chosen as control.All serum samples were tested for sEng with enzyme-linked immunosorbent assay（ELISA）.Results No significant differences was found in maternal serum level of sEng among the early-onset severe preeclampsia,late-onset severe preeclampsia,normal control and preterm group 0.440 ng/ml（0.526 ng/ml）,0.594 ng/ml（0.457 ng/ml）,0.483 ng/ml（0.194 ng/ml）,0.460 ng/ml（0.204 ng/ml）,Chi-Square=1.371,P=0.712）.Conclusion The predictive value of maternal sEng level in mid-term pregnancy（14 to 20 weeks of gestation）on severe preeclampsia has not yet been confirmed.

关 键 词：重度子痫前期 可溶性ENDOGLIN 

分 类 号：R714.2[医药卫生—妇产科学]