千分之一效能白砷剂改善慢性砷中毒症状的初步临床观察(英文)  

An initial report on the efficacy of a millesimal potency Arsenicum Album LM 0/3 in ameliorating arsenic toxicity in humans living in a high-risk arsenic village

作　　者：Anisur Rahman Khuda-Bukhsh Antara Banerjee Surjyo Jyoti Biswas Susanta Roy Karmakar Pathikrit Banerjee Surajit Pathak Bibhas Guha Saiful Haque Debarsi Das Arnab De Durba Das Naoual Boujedaini 

机构地区：[1]Department of Zoology,Laboratory of Cytogenetics and Molecular Biology,University of Kalyani,Kalyani 741235,India [2]Department of Surgical and Gastroenterological Science,University of Padova,Padova,Italy [3]Department of Zoology,Netaji Subhas Open University,Kolkata 700020,India [4]Boiron Laboratory,20 rue de la Liberation,Sainte-Les-Foy-Lyon,Lyon,France

出　　处：《中西医结合学报》2011年第6期596-604,共9页Journal of Chinese Integrative Medicine

摘　　要：背景:全世界有数以百万计的人饮用砷污染的地下水,而目前尚未有缓解慢性砷中毒症状的有效制剂。文献报道白砷剂LM0/3作为一种顺势疗法强化制剂,对于砷中毒症状有一定的治疗作用。目的:本研究旨在验证白砷剂LM0/3对由于生活环境所致而长期饮用砷污染水的人群的慢性砷中毒症状的缓解作用。设计、场所、对象和干预措施:本研究为双盲安慰剂对照研究,参加本研究的28名志愿者来自印度西孟加拉邦纳迪亚区一村落,该村无不含砷的饮用水可用,水井中的含砷量为55～95μg/mL。受试者分别服用药物或安慰剂,在参加试验前及2个月后试验结束时提供血、尿样本。另有18名来自无砷污染饮用水村的志愿者提供血、尿样本作为阴性对照。主要结局指标:测量受试者血、尿样本中的砷含量,各类中毒生物标记物及病理生理指标。结果:28名受试者中,14名愿意提供血、尿样本,其余14名退出试验。受试者的血、尿样本检测出砷的浓度升高,碱性磷酸酶及酸性磷酸酶水平升高,脂质过氧化反应及谷胱甘肽活性升高,血糖、三酰甘油、总胆固醇及低密度脂蛋白胆固醇水平升高,天门冬氨酸氨基转移酶及丙氨酸氨基转移酶水平、γ谷氨酰转移酶及葡萄糖6磷酸脱氢酶含量降低,高密度脂蛋白胆固醇水平及红细胞压积降低。2个月后,用药组的上述指标均有所改善,基质金属蛋白酶活性较安慰剂组有所降低。结论:在尚未有更好的医疗条件和治疗手段的情况下,使用白砷剂LM0/3在饮用水受砷污染地区作为暂时的治疗手段以缓解生活在这些地区的人们的慢性砷中毒症状有一定的可行性。Background：Millions of people are at risk of groundwater arsenic contamination,and there is no known remedy that can effectively remove the symptoms of prolonged arsenic poisoning.A potentized homeopathic drug,Arsenicum Album LM 0/3（Ars Alb LM 0/3）,is claimed in homeopathic literature to have the ability to treat symptoms similar to that of arsenic poisoning.Objective：This study examines whether Ars Alb LM 0/3 could provide some degree of amelioration for the victims living in an arsenic-affected village where no arsenic-free drinking water is available.Design,setting,participants and interventions：This study was carried out on volunteers living in an arsenic-affected village where no arsenic-free drinking water is available.Twenty-eight volunteers from the village of Dasdiya,in Haringhata block under Nadia District,West Bengal,India,an arsenic-contaminated village where wells contain 55 to 95 μg/L arsenic,were selected to undertake a double-blind and placebo-controlled trial.The subjects provided samples of blood and urine before and after 2 months of taking either ＂verum＂ or ＂placebo＂.Another 18 subjects living in an arsenic-free village,served as the negative controls.Main outcome measures：Samples of blood and urine from the subjects were assayed for arsenic content,according to various toxicity biomarkers and pathophysiological parameters.Results：Out of the original 28 subjects,only 14 subjects provided samples while the other 14 dropped out.There were elevated levels of arsenic in the blood and urine,alkaline and acid phosphatases,lipid peroxidation,and glutathione activities and increased blood glucose,triacylglycerol,cholesterol,and low-density lipoprotein cholesterol contents,whereas there were decreased levels of aspartate and alanine aminotransferases,gamma glutamyl transferase,glucose-6-phosphate dehydrogenase contents,high-density lipoprotein cholesterol and packed cell volume in the subjects.After 2 months of homeopathic remedy administration,the verum-fed subjects showed posit

关 键 词：砷剂 顺势疗法 砷中毒 生物学标记 基质金属蛋白酶类 临床试验 

分 类 号：R595.2[医药卫生—内科学]