失血性休克的大鼠肠系膜动脉节律基因表达的变化  

Changes of circadian gene expressions in superior mesenteric artery of rats after hemorrhagic shock

作　　者：张惠琴[1] 谢一舟[1] 田国华[1] 刘延友[1] 汪宇辉[1] 江舟[1] 王正荣[1] 

机构地区：[1]卫生部时间生物学重点实验室四川大学华西医学中心,四川成都610041

出　　处：《四川生理科学杂志》2011年第2期51-52,共2页Sichuan Journal of Physiological Sciences

基　　金：国家自然科学基金资助课题(NO.30470623)

摘　　要：目的:建立失血性休克大鼠模型及探讨失血性休克大鼠肠系膜上动脉(SMA)节律基因表达的变化。方法:建立失血性休克大鼠模型并随机分为失血性休克组和空白对照组,通过RT-PCR检测模型肠系膜上动脉节律基因per1、per2 mRNA的表达水平。结果:休克组与对照组相比,前者肠系膜上动脉节律基因per1、per2的mRNA表达降低(p<0.05)。结论:失血性休克模型肠系膜上动脉节律基因per1、per2表达水平下调,提示失血性休克可以影响节律基因的表达。Objective： To establish the rat model of hemorrhagic shock and to explore the changes of per1 and per2 gene expressions in superior mesenteric artery of rats after hemorrhagic shock.Methods： The rat model of hemorrhagic shock is established.The hemorrhagic shock group and control group were set.The per1 and per2 mRNA expression of SMA were measured by RT-PCR.Results： The level of per1 and per2 mRNA in shock group is lower than in the control group（p0.05）,Conclusion： The per1 and per2 gene expressions in SMA of rats after hemorrhagic shock is decreased,which indicates hemorrhagic shock may affect the expression of circadian genes.

关 键 词：失血性休克 肠系膜上动脉 节律基因 

分 类 号：R657.2[医药卫生—外科学]