因卡膦酸二钠治疗恶性肿瘤骨转移性疼痛的临床观察  

Efficacy and Safety of Incadornate for Malignant Osseous Metastasis Pain

作　　者：莫晨[1] 黄燕苹[1] 吴小娥[1] 陕海丽[1] 徐铭宝[1] 

机构地区：[1]武警总医院干部病房二科,北京100039

出　　处：《中国医院用药评价与分析》2011年第6期549-551,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:评价因卡膦酸二钠治疗恶性肿瘤骨转移性疼痛的有效性和安全性。方法:应用因卡膦酸二钠治疗恶性肿瘤骨转移患者28例,并与帕米膦酸二钠治疗组30例进行对照研究,观察2组止痛疗效、生活质量改善程度及不良反应。结果:因卡膦酸二钠治疗组止痛有效率为75.0%,生活质量改善有效率为53.6%,均优于帕米膦酸二钠组,不良反应少于帕米膦酸二钠组。结论:因卡膦酸二钠高效缓解恶性肿瘤骨转移所致的骨痛,并且应用安全,耐受性良好,值得临床推广使用。OBJECTIVE：To evaluate the efficacy and safety of incadronate disodium for osseous metastatic pain in patients with malignant cancer.METHODS：A total 58 patients with malignant osseous metastasis were enrolled in this control study,28 were assigned to receive incadronate disodium and 30 to receive pamidronate disodium（n=30）.The pain-relieving efficacy,improvement in quality of life and side effects in the two groups were followed.RESULTS：The effective rate in pain-relieving was 75.0% and that in improvement of quality of life was 53.6% in incadronate disodium-treated group,all superior to the pamidronate disodium-treated group;however,the side reactions in the incadronate disodium-treated group were milder than in the pamidronate disodium-treated group.CONCLUSION：Incadronate disodium was proved to be safe and effective for relieving malignant osseous metastasis pain and well-tolerated,hence its clinical use is worthy of recommendation

关 键 词：因卡膦酸二钠 帕米膦酸二钠 骨转移癌 骨痛 

分 类 号：R979.1[医药卫生—药品]