阿仑磷酸钠联合复方丹参片治疗绝经后骨质疏松症患者的效果评价  

Effect analysis of compound danshen tablets plus alendronate in treatment of women with postmenopausal osteoporosis

作　　者：梁玉梅[1] 吴微波 侯腊梅 

机构地区：[1]广东医学院附属医院骨科二区,湛江524001 [2]江门市蓬江区白石正骨医院 [3]湛江市卫生学校

出　　处：《中国实用护理杂志》2011年第18期29-31,共3页Chinese Journal of Practical Nursing

基　　金：湛江市科技攻关项目[湛科（2009）63号]

摘　　要：目的探讨复方丹参片联合福善美（阿仑磷酸钠）治疗妇女绝经后骨质疏松症，评价其疗效及安全性。方法将180例绝经后骨质疏松症患者随机分为福善美组、丹参组和复方丹参片联合福善美组（简称联合组）。分别采用相应药物进行治疗，疗程6个月，比较2组碱性磷酸酶、骨钙素、尿钙、尿肌酐、尿羟脯氨酸含量及腰1～5骨密度值。结果联合组的碱性磷酸酶、骨钙素、尿钙、尿肌酐、尿羟脯氨酸、腰1～5骨密度值与其他2组比较差异显著。结论福善美联合复方丹参片治疗绝经后妇女骨质疏松症安全有效。Objective To assess whether treatment with compound danshen tablets plus alendronate would be safe and effective in women with postmenopausal osteoporosis. Methods 180 women with postmenopausal osteoporosis were randomized to receive combination therapy and independent therapy with compound danshen tablets and alendronate for 6 months. Scores of VRS were assessed, mean serum alkaline phosphatase, serum osteocalcin, urinary creatinine, urinary hydroxyproline, urinary calcium were detected. Bone mineral density of lumbar vertebra 1 -5 was determined by dual X- ray absorptiometry. Results Mean serum alkaline phosphatase, serum osteocalcin, and urinary creatinine, urioary hydroxyproline, urinary calcium were statistically different between the combination lherapy group and the independent therapy group, and bone mineral densities increased in all therapy groups while there was higher elevated level in the combination therapy group. Conclusions The combination therapy of cornpound danshen tablets with alendronate has a favorable influence on women with postmenopausal osteoporosis.

关 键 词：福善美 复方丹参片 绝经后妇女 骨质疏松 

分 类 号：R580[医药卫生—内分泌]