肺泡蛋白沉积症胸部高分辨率CT诊断  

High Resolution CT Diagnosis of Pulmonary Alveolar Proteinosis

作　　者：肖树恺[1] 朱宇辉[1] 蔡汉寿[1] 

机构地区：[1]深圳市龙岗区人民医院影像科,广东深圳518172

出　　处：《实用放射学杂志》2011年第6期883-885,共3页Journal of Practical Radiology

摘　　要：目的探讨高分辨率CT（HRCT）对肺泡蛋白沉积症（PAP）的诊断价值。方法回顾性分析6例确诊的PAP患者胸部CT表现与相应病理学改变。结果在HRCT上，6例患者在不同层面可见磨玻璃影，4例表现为两肺斑片状磨玻璃影与周围肺组织分界清楚，呈地图样改变，3例因肺小叶间隔增厚交织成铺路石样改变，3例可见肺泡实变融合成密度较高的斑片状阴影。3例患者活检肺组织在光镜下显示肺泡腔内充满大量块状或颗粒状嗜伊红物质，PAS染色阳性，AB染色阴性，其中1例肺泡间隔正常，2例肺泡间隔增宽，可见成纤维细胞增生和胶原沉积。结论PAP的胸部HRCT表现与病理改变一致，具有一定的特征性，对提高本病的诊断具有重要价值。Objective To study high resolution CT（HRCT） features and relative pathological characteristics of pulmonary alveolar proteinosis （PAP）. Methods HRCT features and pathologic characteristics of PAP in 6 patients were retrospectively analysed. Results HRCT showed ground-glass opacity at different section in 6 cases,patch-like ground-glass shadows with definite margins and as map-like in 4 cases, ＂cobble stone like＂ lesions in 3 cases, multifocal consolidation opacity in 3 cases. 3 patients showed alveolar massive eosinophilic exudation at pathology,positive at PAS staining and negative at AB staining,of them,the alveolar septum was normal in 1 patient,the thickening of the septum in 2 cases and having fibroblast hyperplasia and interstitial fibrosis. Conclusion HRCT findings of PAP of chest are fairly correspond with that of pathological changes,it is very important to improve the diagnosis of this disease.

关 键 词：肺 肺泡蛋白沉积症 体层摄影术 X线计算机 

分 类 号：R563[医药卫生—呼吸系统] R814.42[医药卫生—内科学]