兔膝类风湿关节炎模型关节腔内注射BMSCs后滑膜体积变化的MRI观察  

MR Imaging Observation on the Changes of the Volume of Synovium in Rheumatoid Arthritis of Rabbit with BMSCs Transplantation

作　　者：崔延安[1] 刘钊[1] 刘红霞[1] 黄海青[1] 张全彬[2] 

机构地区：[1]江苏省中医院MR室,江苏南京210029 [2]南京医科大学附属南京第一医院骨科中心

出　　处：《实用放射学杂志》2011年第6期946-949,共4页Journal of Practical Radiology

基　　金：江苏省自然科学基金面上项目（编号：BK2009460）.

摘　　要：目的评价骨髓间充质干细胞（BMSCs）治疗兔早期类风湿关节炎（RA）治疗效果。方法选取42只新西兰大白兔，用卵蛋白造模，造模第4周（治疗前）取6只兔行MR和病理检查以对照，余36只兔随机分RA模型组和BMSCs治疗组，每组18只，2组于治疗后1、2、3个月分别选取6只兔行MR和病理检查。对病变膝关节的滑膜体积进行MRI测量及病理学评分，并对数据进行统计学分析。结果RA模型组经1、2、3个月后滑膜进行性增厚，病理学评分增加。BMSCs治疗组治疗1、2、3个月后，滑膜增厚程度减轻，病理学评分减低。MRI测量数据和病理学评分呈正相关。结论MRI可用于临床对类风湿关节炎的疗效评价；BMSCs可抑制类风湿关节炎的炎症反应。Objective To analyze the effects of BMSCs transplantation in early rheumatoid arthritis （RA） of rabbits. Methods 42 RA models of New Zealand white rabbits were induced by injecting ovalbumin into right knee joints of them,6 rabbits were used as controls and MR imaging and pathology of knee joints in control group were clone at 4 weeks later after injection. Thirty-six else rabbits were randomly and equally （18 rabbits in each group） divided into an early RA models group （group A）and BMSCs transplantation group （group B）. MR imaging and pathology of knee joints were done at 1, 2, 3 months after injection in both group A and B. The volume of synovium of the knee joints were measured by MRI, and pathohistological changes were observed and scored. The data were statistically analysed. Results Group A after 1, 2, 3 months showed synovium thickening and higher pathological scores, and group B showed synovium thinning and lower pathological scores. The correlation between MRI and pathology was remarkable. Conclusion MRI can show the effect of the early stages of RA in treatment. BMSCs can restrain inflammatory reaction in RA models of rabbits.

关 键 词：类风湿关节炎 磁共振成像 兔 骨髓间充质干细胞 

分 类 号：R593.22[医药卫生—内科学] R445.2[医药卫生—临床医学]