吸烟致冠状动脉慢血流现象研究  

Cigarette smoking causes slowing of coronary blood flow

作　　者：范小明[1] 吕安康[1] 沈卫峰[1] 马晓晔[1] 吴祁红[1] 杨二丽[1] 张瑞岩[1] 张奇[1] 

机构地区：[1]上海交通大学医学院附属瑞金医院心内科,上海200025

出　　处：《内科理论与实践》2011年第3期200-203,共4页Journal of Internal Medicine Concepts & Practice

摘　　要：目的:评估吸烟对冠状动脉造影正常者血流速度的影响。方法:连续性选择冠状动脉造影正常的男性患者123例,依据吸烟情况,分为吸烟组(57例)和非吸烟组(66例)。计算左前降支、左回旋支和右冠状动脉的心肌梗死溶栓(TIMI)血流帧数及全冠状动脉的平均TIMI血流帧数,分析缓慢血流及其相关危险因素。结果:与非吸烟组比较,吸烟组的TIMI血流帧数(左前降支41.43±15.29比36.5±11.75,左回旋支29.48±9.95比23.43±12.54,右冠状动脉25.33±10.92比20.63±11.28,均P﹤0.05)和全冠状动脉平均TIMI血流帧数(31.23±13.11比27.12±9.68,P﹤0.05)均显著增高。吸烟、肥胖、糖尿病和高脂血症为冠状动脉缓慢血流的独立危险因素。结论:吸烟者的冠状动脉尽管形态正常,但是其血流速度已受损。Objective To study the influence of cigarette smoking on coronary blood flow in patients with normal coronary artery angiography.Methods One hundred and twenty three patients with normal coronary artery angiography were divided into smoking group（57 patients） and non-smoking group（66 patients） according to their cigarette smoking status.Thrombolysis in myocardial infarction（TIMI） frame counts of left anterior descending artery,left circumflex artery and right coronary artery and average TIMI frame counts of overall major coronary arteries were calculated.Analyzed the slowing of coronary blood flow and their related risk factors.Results TIMI frame counts of left anterior descending artery（41.43±15.29 vs 36.5±11.75,P0.05）,left circumflex artery（29.48±9.95 vs 23.43±12.54,P0.05）,right coronary artery（25.33±10.92 vs 20.63±11.28,P0.05） and average TIMI frame counts of overall major coronary arteries（31.23±13.11 vs 27.12±9.68,P0.05） in smoking group were significantly higher than those in non-smoking group.Smoking,obesity,diabetes mellitus and hyperlipidemia were the independent risk factors of slowing of coronary blood flow.Conclusions In smokers,coronary blood flow was impaired despite the morphology of coronary artery remains in normal range.

关 键 词：吸烟 冠状动脉 心肌梗死溶栓 血流帧数 慢血流 

分 类 号：R542.22[医药卫生—心血管疾病]