中老年食蟹猴群体自发型糖尿病的筛选  

Screening of spontaneous diabetes mellitus in middle-and old-aged cynomolgus monkey

作　　者：万玉玲 张艳春[2] 彭白露 李学家[2] 季芳[2] 靳丽莎[2] 饶军华 刘晓明[1,2] 

机构地区：[1]广东蓝岛生物技术有限公司,广东广州510555 [2]广东省昆虫研究所,广东广州510260

出　　处：《Zoological Research》2011年第3期307-310,共4页动物学研究（英文）

基　　金：广州市科技计划项目(2009A1-E051;2010U1-E00811);广东省林业局项目(2009KJCX016);国家"十二五"项目(2011ZX09307-03-303)

摘　　要：筛选440只中老年偏胖食蟹猴群体中自发糖尿病个体,并探讨食蟹猴群体中糖尿病粗筛的方法。以调查基础血糖值为基础,推断疑似糖尿病血糖值,后经OGTT(口服糖耐量)和尿检结果验证该血糖值是否准确。结果显示中老年偏胖食蟹猴群体血糖值为(3.88±0.98)mmol/L,其中56只食蟹猴血糖值大于5.0mmol/L,被初步定为糖尿病个体。这些个体全部糖耐量异常,且36只(69.23%)出现尿糖阳性,证明血糖值大于5.0mmol/L可作为本群体食蟹猴糖尿病的粗筛标准。由于针对中老年偏胖食蟹猴群体,患病率为12.72%(56/440),高于我国糖尿病患病率(9.7%)。虽然该实验的糖尿病血糖指标并不适用于所有食蟹猴群体,但是该筛选的流程简单快捷,对动物损伤小,可适用于大群体糖尿病的筛选。To screen spontaneous diabetic mellitus and explore methods for its rapid identification,the basal and inferred levels of blood glucose of 440 overweight,middle-and old-aged cynomolgus monkeys were analyzed.Diagnostic diabetes was further validated by the oral glucose tolerance test（OGTT） and urine glucose.The average level of blood glucose of these cynomolgus monkeys was（3.88±0.98） mmol/L,which was lower than the level for suspected diabetes（5.0 mmol/L）.Of them,56（12.72%） monkeys were identified with levels of blood glucose greater than 5.0 mmol/L and diagnosed as the diabetic subjects.This population showed impaired glucose tolerance using the OGTT and 39 of the 56（69.23%） had glucose positive urine.The methods for screening diabetic mellitus used in this study were simple,quick,and limited the harm to animals.However,the incidence of diabetes was higher in these tested monkeys than in the regular human population in China（9.7%）,suggesting that these methods are useful for screening diabetic disease in a large population but not suitable for all cynomolgus monkeys.

关 键 词：自发性糖尿病 筛选 血糖 食蟹猴 

分 类 号：S858.91[农业科学—临床兽医学]