穿心莲内酯在减缓深静脉血栓形成中作用机制的研究  

The mechanism of andrographolide retarding the development of deep vein thrombosis in mice

作　　者：王玉玖[1] 张刚[2] 王岩[2] 邹承伟[2] 王安彪[2] 王晶[3] 耿建国[4] 王尽淘[4] 范全心[2] 

机构地区：[1]山东省滨州医学院附属医院心脏外科,滨州256603 [2]山东大学附属山东省立医院心脏外科,济南250021 [3]山东省滨州医学院附属医院口腔内科,滨州256603 [4]中国科学院上海生物化学与细胞生物研究所,上海200314

出　　处：《中国体外循环杂志》2011年第2期115-117,124,共4页Chinese Journal of Extracorporeal Circulation

基　　金：国家自然科学基金项目(30971676);山东省自然科学基金项目(Y2005C26)

摘　　要：目的研究穿心莲内酯抑制NF-кB信号通路的作用机制。方法建立深静脉血栓的小鼠动物模型,取血栓标本,测量裸栓长度并称重。检测E-selectin、VCAM-1和Fibrin的表达,白细胞浸润密度等指标。结果应用穿心莲内酯处理的小鼠血栓E-selectin、VCAM-1、Fibrin的表达显著下降,白细胞浸润密度显著下降。结论穿心莲内酯能抑制NF-кB信号通路,进而起到显著抑制深静脉血栓的作用。OBJECTIVE To research the mechanism of andrographolide inhibit the NF-κB signaling pathway.METHODS The model of deep-vein thrombosis in mice was established to obtain thrombus specimens,detect the espression of E-selectin,VCAM-1 and Fibrin,and observe the density of leukocyte infiltration.RESULTS The espression of E-selectin,VCAM-1 and Fibrin,and the density of leukocyte infiltration were decline in the thrombus specimens treated by andrographolide in mice.CONCLUSION Andrographolide can inhibit the NF-κB signaling pathway.

关 键 词：穿心莲内酯 深静脉血栓 NF-кB 

分 类 号：R286.0[医药卫生—中药学]