中性粒细胞明胶酶相关脂质运载蛋白作用于肿瘤的二重性  

Dual effects of neutrophil gelatinase associated lipocalin on neoplasmas

作　　者：王毅钧[1] 彭林[1] 

机构地区：[1]广东省人民医院血管甲状腺腹壁疝外科,广州510080

出　　处：《国际外科学杂志》2011年第6期396-399,共4页International Journal of Surgery

摘　　要：中性粒细胞明胶酶相关脂质运载蛋白（NGAL）在多种恶性肿瘤中都有不同程度的表达升高，并参与肿瘤的发生发展，但其对肿瘤的作用似乎存在相互矛盾的二重性。例如在乳腺癌和食管癌中通过保护MMP-9的自身降解，NGAL可促进肿瘤生长和转移。然而在胰腺癌和卵巢癌中，NGAL可通过抑制FAK的磷酸化和VEGF的合成而起到了抑制肿瘤演进的作用。本综述总结了NGAL在肿瘤发生发展中的二重性作用，并探讨引起二重性作用的可能机制。Neutrophil gelatinase associated lipocalin （NGAL）, also known as lipocalin 2 ,has close relationship with human neoplasias, which is up-regulated in a number of malignancy and involves in the process of tumor development. But it appears to exist paradoxical effects attributed to NGAL in human neoplasias. For instance, through protecting MMP9 from autodegradation, NGAL has a clear pro-tumoral and pro-metastatic effect, as has already been observed in breast cancer and esophageal cancer. However, on the contrary, for pancreatic cancer and ovarian cancer, NGAL can inhibit FAK phosphorylation and vascular epidermal growth factor synthesis, having an anti-tumoral and anti-metastatic effect. This review summarizes the current knowledge about the dual effects of NGAL in the process of tumor development, and attempts to explore the possible undedyins mechanism.

关 键 词：中性粒细胞明胶酶相关脂质运载蛋白 肿瘤 

分 类 号：R692[医药卫生—泌尿科学]