HPLC柱切换法比较轻度烧伤感染与中度烧伤感染患者头孢吡肟的血药浓度  

Comparison of Cefepime concentration for treatment of infection in mild degree burn and second degree burn by switching HPLC

作　　者：段晓霞 郑小林[2] 张春玉 

机构地区：[1]广东公安边防总队第七支队卫生队,518029 [2]武汉市中心医院普通外科 [3]广东公安边防总队特检站卫生队

出　　处：《中国实用医药》2011年第17期21-23,共3页China Practical Medicine

摘　　要：目的为优化烧伤感染患者的抗菌药物给药方案提供理论依据。方法柱切换反相高效液相色谱法比较轻度烧伤感染患者和中度烧伤感染患者的血药浓度。结果滴注2g头孢吡肟后,中度烧伤感染组的血药浓度与轻度烧伤感染组的血药浓度差异有统计学意义(P<0.05)。结论应适当缩短中度烧伤感染患者的头孢吡肟的滴注的间隔时间或增大其用药剂量。Objective To provide a theoretical basis for anti-bacteria for treatment of infection of burn. Methods Both Cefepime concentrations in mild degree burn and second degree burn were determined by reversed-phase high-performance liquid chromatography（R-HPLC）. Results There was significant difference between concentration of Cefpime in mild degree burn group and second degree burn by test（P〈0.05）.Conclusion The necessity of larger and/or more frequently administered doses may be adequate in treatment of infection in second degree burn.

关 键 词：烧伤感染 头孢吡肟 柱切换 高效液相色谱法 

分 类 号：R644[医药卫生—外科学]