乌司他丁联合甲强龙治疗百草枯中毒的疗效研究  

Effect of Ulinastatin Combined with Methylprednisolone on Paraquat Poisoning

作　　者：范小勇[1] 许震[1] 郝向峰[1] 

机构地区：[1]新乡市中心医院急诊科,453000

出　　处：《中国实用医药》2011年第17期53-55,共3页China Practical Medicine

摘　　要：目的评价乌司他丁联合甲强龙治疗百草枯中毒的临床疗效。方法选择我院急诊2006年7月至2010年12月收治的急性百草枯中毒患者53例,随机分为对照组(26例)与治疗组(27例)。对照组给予常规治疗。治疗组在对照组的基础上应用乌司他丁注射液50ml,2次/d,连用7d;甲强龙500mg,1次/d,连用5d。结果治疗组有效率为59.25%,对照组有效率为42.3%,且两组总有效率比较有统计学差异(P<0.05)。治疗组发生低氧血症、Ⅰ型呼吸衰竭与使用机械通气例数显著低于对照组(P<0.05)。结论乌司他丁联合大剂量甲强龙治疗可减轻百草枯中毒患者的损伤程度,降低患者死亡率。Objective To evaluate the therapeutic effect of Ulinastatin combined with methylprednisolone on Paraquat poisoning with lung injury. Methods 53 patients with acute paraquat poisoning were ramdomly divided into control group（26 cases）and treatment group（27 cases）. Control group was given basic therapy. Treatment group received Ulinastatin（50 ml, twice perday）and methylprednisolone（500 mg, once perday）for 7 d and 5 d respectively, other treatments were the same as control group. Results Compared to the control group, the incidence of hypoxemia, Ⅰtype respiratory failure, mechanical ventilation of treatment group reduced noably.（P〈0.05）; the cases of death of treatment groups decreased（P〈0.05）. Conclusion Ulinastatin,combined with methylprednisolone can reduced the extent of lung injury and mortality of patients with paraquat poisoning.

关 键 词：乌司他丁 甲强龙 百草枯中毒 

分 类 号：R595.4[医药卫生—内科学]