Predictive biomarker and clinicopathological characteristics analysis for recurrence of early gastric cancer  

与早期胃癌复发有关的临床病理特性及生物指标的分析(英文)

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作  者:Jiyuan Yang Zhiqiang Cai Wei Du Junchuan Li Tingxuan Chen Yunhua Xu 

机构地区:[1]Department of Oncology, The First Affiliated Hospital, Yangtze University, Jingzhou 434000, China [2]The Medical College of Yangtze University, Jingzhou 434000, China [3]Department of Pathology, The First Affiliated Hospital, Yangtze University, Jingzhou 434000, China

出  处:《The Chinese-German Journal of Clinical Oncology》2011年第7期394-398,共5页中德临床肿瘤学杂志(英文版)

摘  要:Objective: The aim of this study was to identify the correlation between the clinicopathological characteristics and recurrence in early gastric cancer (EGC), what's more, we attempt to look for a predictive biomarker to predict and treat for re-currence of EGC. Methods: This study retrospectively analyzed 178 early gastric cancer patients who had the complete post-operative and follow-up medical records in the First Affiliated Hospital of Yangtze University (China) between January 1995 to December 2005. All of them were followed-up to December 2009 regularly. Computer tomography (CT), endoscopy, and single photon emission computed tomography (SPET-CT) were used to diagnose for recurrence of EGC. Immunohistochem-istry (IHC) and fluorescence in situ hybridization (FISH) were used for the detection of cerbB2. Chi-square test was applied to this study for statistics analysis. Results: Fourteen patients had recurrence. Eighteen patients were cerbB2-positive, including twelve recurrence patients and six norecurrence patients. Sex, tumor depth, and lymph node metastasis were related to the recurrence of EGC. Also, cerbB2-positive patients had the higher recurrence rate compared to the cerbB2-negative patients. Conclusion: Recurrence of EGC after curative resection can be predicted by using some clinicopathological characteristics. CerbB2 can be used as a predictive biomarker for recurrence of EGC.

关 键 词:early gastric cancer (EGC) RECURRENCE gene CERBB2 immunohistochemistry (IHC) fluorescence in situ hybridization (FISH) 

分 类 号:S858.23[农业科学—临床兽医学] P618.130.1[农业科学—兽医学]

 

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