MCP-1/CCR2基因多态性与冠状动脉疾病关联性的Meta分析  

Meta-analysis on the association between MCP-1/CCR2 genes polymorphisms and coronary artery disease

作　　者：朱军[1] 蒯正平[1] 严建军[1] 王泽穆[1] 唐建金[1] 杨志健[1] 王连生[1] 

机构地区：[1]南京医科大学第一附属医院心内科,江苏南京210029

出　　处：《南京医科大学学报（自然科学版）》2011年第6期827-833,共7页Journal of Nanjing Medical University(Natural Sciences)

基　　金：国家自然科学基金资助(30871078)

摘　　要：目的:采用Meta分析探讨单核细胞趋化蛋白-1(monocyte chemotactic protein-1,MCP-1)基因的G2518A位点及趋化因子受体2(CC chemokine receptor 2,CCR2)基因的G190A位点多态性与冠状动脉疾病(coronary artery disease,CAD)的关联性。方法:通过PubMed,EMbase,CNKI及CBM等数据库搜索关于MCP-1/CCR2基因多态性与CAD关联性的文章。结果:符合纳入标准的共有21篇文献,MCP-1基因的G2518A位点和CCR2基因的G190A位点分别有6 835例CAD患者、11 142例正常对照受试者,以及2 801例CAD患者、5 789例正常对照受试者入选。综合数据表明MCP-1基因的G2518A位点和CCR2基因G190A位点多态性与CAD的发生存在关联[G2518A(P=0.04),G190A(P=0.005)]。根据分层分析观察到MCP-1基因的G2518A位点在非亚洲人群中与CAD存在关联性(P=0.04),而在亚洲人群中与CAD不具有统计学意义(P>0.05)。结论:MCP-1基因的G2518A位点及CCR2基因的G190A位点多态性与CAD的发生具有统计学意义。Objective：To assess the association of monocyte chemotactic protein-1（MCP-1）gene G2518A and CC chemokine re-ceptor 2（CCR2）gene G190A polymorphisms with coronary artery disease（CAD）.Methods：Databases,including PubMed,EMbase,CNKI and CBM,were searched to get the association studies on MCP-1 /CCR2,RANTES /CCR5 genes polymorphisms and CAD.Results：A total of 21 case-control studies were identified.The Meta-analysis included 6 835（MCP-1-G2518A）CAD case and 11 142 controls,2 801 CAD cases and 5 789 controls（CCR2-G190A）,respectively.MCP-1 gene G2518A polymorphism was significantly as-sociated with CAD（P = 0.04）.The CCR2 gene G190A polymorphism was also significantly associated with the presence of CAD（P = 0.005）.In stratified analysis by race,the MCP-1 gene G2518A polymorphism was significantly associated with the presence of CAD in non-Asian（P = 0.04）,while not in Asian（P 〉 0.05）.Conclusion：Our results showed that the MCP-1 gene G2518A and CCR2 gene G190A polymorphisms were associated with an increased risk of CAD.

关 键 词：单核细胞趋化蛋白-1/趋化因子受体2 基因多态性 冠状动脉疾病 META分析 

分 类 号：O213[理学—概率论与数理统计]