用自身对照的方法研究复氧对缺氧狗心脏功能的影响  

Research on effect of oxygen-reuptake on cardiac functions of anoxic dogs by self-reflection method

作　　者：何薇[1,2] 但国蓉[1] 唐禾[1] 蔡颖[1] 何悦[1] 董兆君[1] 

机构地区：[1]第三军医大学军事预防医学院防化医学教研室,重庆400038 [2]昆明市延安医院内分泌科,云南昆明650051

出　　处：《局解手术学杂志》2011年第4期385-387,共3页Journal of Regional Anatomy and Operative Surgery

基　　金：军队"十一五"医学科研基金攻关项目(06G077)

摘　　要：目的用自身对照法研究复氧对缺氧狗心脏功能的干预作用。方法雄性四川杂种家犬6只,以戊巴比妥钠麻醉后行气管插管术、左心室插管术和右侧股动脉插管术。采用自身对照法,先使动物经气管插管吸入常氧空气,继之吸入缺氧气体,最后重新吸入常氧空气。于缺氧前60 min、缺氧前30 min、缺氧前10 min、缺氧10 min、缺氧30 min、缺氧60 min、复氧10 min、复氧30 min和复氧60 min记录心率(HR)、左心室收缩压(LVSP)和左心室压最大上升速率(+dp/dtmax)、股动脉血氧分压PaO2和二氧化碳分压PaCO2。结果吸入缺氧气体后动物心率逐渐加快,LVSP先增加后下降,股动脉血PaO2明显下降,而PaCO2明显升高。复氧后上述指标逐渐恢复。结论吸入缺氧性混合气体可以导致狗心脏功能的明显改变,复氧能有效改善缺氧引起的这些变化。Objective To study the intervention effect of oxygen-reuptake on cardiac functions of anoxic dogs by self-reflection method.Methods Six male hybrid dogs were used in the present study.The dogs were anaesthetized with pentobarbital sodium and were fixed on the operating tables.The catheterizations of trachea,left ventricle and femoral artery were performed.The dogs first inhaled normal air followed by mixture of oxygen and nitrogen and then inhaled normal air again.Records were taken at 60min,30min,10min before hypoxia and 10 min,30 min,60min at hypoxia and 10 min,30 min,60min at oxygen-reuptake.The bio-signals of heart rate（HR）,left ventricle systolic pressure（LVSP） and ＋dp/dtmax were recorded.Arterial partial pressure of oxygen（PaO2） and arterial partial pressure of carbon dioxide（PaCO2） were analyzed by automatic blood gas system.Results Heart rates of dogs were increased gradually by inhaling the mixture of oxygen and nitrogen.LVSP,however,experienced a process of increase at 10 min and 30min and decrease at 60min.Decreased PaO2 and increased PaCO2 were observed during the inhalation of anoxic air.Conclusion Anoxic air inhalation could affect the cardiac functions of the dogs and oxygen-reuptake could ameliorate these changes.

关 键 词：缺氧 复氧 心脏功能 犬 

分 类 号：R594.3[医药卫生—内科学]