铬对大鼠听力的损伤及锌、硒的拮抗作用  

Auditory changes caused by chromium and antagonistic effects of zinc or selenium

作　　者：杨燕[1] 李宁[2] 于江[2] 张珂[2] 吴淑荣[2] 高希宝[2] 

机构地区：[1]山东大学齐鲁医院耳鼻咽喉-头颈外科 [2]山东大学公共卫生学院卫生检验研究所,济南250012

出　　处：《山东大学耳鼻喉眼学报》2011年第3期37-40,共4页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的研究铬中毒对大鼠听力功能的损伤以及锌、硒对铬中毒大鼠听力的保护作用。方法将40只雌雄各半的W istar大鼠随机分成对照组(A)、铬染毒组(B)、锌(染铬)保护组(C)、硒(染铬)保护组(D)4组,连续灌胃30 d后,通过脑干电诱发电位测定大鼠听力功能。结果与A组相比,B组听觉脑干电诱发电位图(ABR)极为平缓,其Ⅰ、Ⅱ波潜伏期明显延长,波峰幅度明显降低;C组大鼠ABR两波潜伏期短于B组,D组大鼠ABR两波潜伏期明显短于B组而高于A组,C、D两组的两波波峰明显高于B组而低于A组。结论铬中毒对大鼠听力造成一定伤害,锌、硒对这种伤害具有一定的保护作用,硒对铬中毒听力损伤的保护作用强于锌。Objective To study chromium induced hearing damages and protective effects of zinc and selenium on hearing in rats.Methods Twenty male and twenty female Wistar rats were randomly and averagely divided into the control group（A）,the chromium poisoning group（B）,the zinc protective group（C）,and the selenium protective group（D）.After 30 days of oral administration of physiological saline,4mg/kg potassium dichromate,2mg/kg zinc sulfate,and 2mg/kg sodium selenite,their auditory brainstem response（ABR） was detected.Results ABR figures of chromium poisoning groups were extremely flat and theⅠand Ⅱ latencies of ABR waves were much longer and their wave peaks were much lower than those of the control group.TheⅠand Ⅱ latencies of the two ABR waves in group C were a little shorter than those of group B,and the latencies of group D were much shorter than those of group B,but both of them were still longer than those of group A.The two wave peaks of group C and group D were higher than those of group B but lower than those of group A.Conclusions Hearing functions of rats might be partly damaged by chromium and zinc or selenium shows some protective effects.The protection of selenium is stronger than that of zinc.

关 键 词：铬中毒 听力损伤 锌 硒 拮抗作用 

分 类 号：R764.5[医药卫生—耳鼻咽喉科]