正常豚鼠听性脑干反应与听性稳态反应的对比  

Comparison of auditory brainstem response and auditory steady-state response in normal guinea pigs

作　　者：鄢慧琴[1] 王海涛[1] 周枫[1] 黄利芬[1] 

机构地区：[1]广州医学院附属广州市第十二人民医院耳鼻咽喉头颈外科,广州510620

出　　处：《山东大学耳鼻喉眼学报》2011年第3期43-45,共3页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的比较正常豚鼠听性脑干反应（ABR）和听性稳态反应（ASSR）阈值的差异,为利用豚鼠进行听力学研究提供理论依据。方法选正常听力豚鼠12只（24耳）,在戊巴比妥钠镇静状态下,分别行ABR和ASSR测试。ABR为click刺激声,刺激率为11.1次/s,记录ABR的Ⅱ波反应阈值。ASSR载波频率（CF）为0.5、1、2、3、4、6 kHz,调制频率（MF）为154 Hz,记录各载频的反应阈值。结果正常豚鼠ASSR反应阈值高于ABR反应阈值,CF=0.5~4 kHz时,ABR与ASSR阈值间有统计学差异（P〈0.01）;CF=6 kHz时,两阈值间无统计学差异（P〉0.05）。结论正常豚鼠ABR与ASSR阈值间存在较大差值,但ABR与6 kHz的ASSR阈值间无显著差异。故对豚鼠进行听阈评估时,要注意两者间由于ASSR载波频率不同所引起的差异。Objective To compare the difference of the threshold of normal guinea pigs between auditory brainstem response（ABR） and auditory steady state response（ASSR）,and provide a theoretical basis for hearing research on guinea pigs.Methods 12 guinea pigs（24 ears） with normal hearing sedated by pentobarbital sodium were selected for the ABR and ASSR tests.The click-ABR stimulation rate was 11.1 beats/s,and the Ⅱwave thresholds were recorded as the ABR response threshold.The carrier frequencies（CF） of ASSR were 0.5,1,2,3,4 and 6kHz,the modulation frequency（MF） was 154Hz,and the threshold of each carrier frequency was recorded.Results The threshold of ASSR was higher than that of ABR at 0.5-4kHz CF in normal guinea pigs（P0.01）,but no significant difference was found at 6kHz CF（P0.05）.Conclusion There are significant differences in most thresholds of ASSR and ABR in normal guinea pigs.However,there is no significant difference at 6kHz CF.Therefore,the differences caused by different CF of ASSR must be noted when assessing the hearing of guinea pigs.

关 键 词：听性脑干反应 听性稳态反应 豚鼠 

分 类 号：R764.04[医药卫生—耳鼻咽喉科]