慢性鼻窦炎嗅觉障碍嗅上皮中IGF-1R和Ki-67的表达及意义  

IGF-1R and Ki-67 expressions in olfactory epithelium of patients suffering from dysosmia caused by chronic sinusitis

作　　者：刘庆华[1] 李志春[2] 

机构地区：[1]厦门大学附属第一医院耳鼻咽喉-头颈外科,福建厦门361003 [2]福建医科大学附属第一医院耳鼻咽喉-头颈外科,福建福州350004

出　　处：《山东大学耳鼻喉眼学报》2011年第3期55-57,61,共4页Journal of Otolaryngology and Ophthalmology of Shandong University

摘　　要：目的探讨慢性鼻-鼻窦炎嗅觉功能障碍的发病机制和胰岛素样生长因子-1R(insulin-like growth factor 1R,IGF-1R)和Ki-67在嗅黏膜中表达的意义。方法取32例慢性鼻-鼻窦炎患者作为失嗅组,11例单纯鼻中隔偏曲行鼻中隔矫正术者作为对照组,应用免疫组织化学技术检测IGF-1R和Ki-67在两组嗅黏膜表达的分布。结果与对照组相比,实验组嗅黏膜Ki-67和IGF-1R表达明显减少(P<0.05)。结论慢性鼻-鼻窦炎嗅黏膜的再生能力明显减弱,与IGF-1R减少有关。Objective To study the pathogenesis of dysosphresia in patients with chronic sinusitis,and to discuss expressions and significance of IGF-1R and Ki-67 in olfactory mucosa.Methods There were 32 cases of chronic sinusitis in the experimental group,and 11 cases in the control group.IGF-1R and Ki-67 expressions were determined by immunohistochemistry.Tissue sections were observed under an optical microscope.Results Expressions of IGF-1R and Ki-67 in the olfactory epithelium of 32 patients suffering from the dysosmia were lighter than those in the control group（P0.05）.Conclusion IGF-1R promoting regeneration in the olfactory epithelium was notably decreased in the ofactory epithelium of chronic sinusitis patient and may lead to ofactory dysfunction.

关 键 词：胰岛素样生长因子-1R KI-67 鼻窦炎 嗅上皮 嗅觉障碍 

分 类 号：R765.63[医药卫生—耳鼻咽喉科]