利福平/磷酸八钙骨水泥载药体系的制备及体外释放特性  

Preparation and Drug Release Behavior of Octocalcium Phosphate Cement Loaded with Rifampicin

作　　者：孙建英[1] 王德平[1,2] 姚爱华[1] 周萘[1] 黄文旵[1,2] 

机构地区：[1]同济大学材料科学与工程学院 [2]先进土木工程材料教育部重点实验室,上海200092

出　　处：《硅酸盐学报》2011年第7期1184-1188,共5页Journal of The Chinese Ceramic Society

基　　金：国家自然科学基金(50572072/50702037)资助项目

摘　　要：为了研究磷酸八钙骨水泥(octacalcium phosphate,OCP)作为药物载体的体外释药行为,以利福平(rifampicin,RFP)作为模型药物,制备利福平/酸八钙骨水泥药物缓释体系。通过X射线衍射、红外光谱、场发射扫描电镜分析、万能电子试验机及紫外-可见分光光度计等测试方法,研究RFP对OCP的相组成、抗压强度的影响及其释药行为。结果表明:在OCP中添加适量的药物并不会影响最终产物的物相;对于药物含量一定的载体,药物释放时间在5 d后,强度变化趋于稳定;对于药物含量不同的载体,药物含量越高越容易导致载体的孔隙率增大,强度变小;药物含量分别为60 mg/g与40 mg/g的载体的释放特性都符合Higuchi扩散释放模型,但是前者的相关性更好。To study drug release behavior of octocalcium phosphate cement（OCP） as a drug carrier,rifampicin（RFP） was chosen as model drug to prepare OCP loaded with RFP（RFP/OCP）.The X-ray diffraction,Fourier transform infrared spectroscopy,field emis-sion scanning electron microscopy,electronic universal testing,and ultraviolet-visible spectrometry were performed to characterize variation in the composition,compressive strength,and drug release behavior.The results indicate that a certain amount of RFP has no influence on the hydration properties and final composition;for the same RFP/OCP,the compressive strength becomes steady when RFP/OCP is immersed in simulated body fluid for 5 d.However,for OCP with different amounts of RFP,the increased amount of RFP results in higher porosity and smaller compressive strength.OCP with 60 mg/g and 40 mg/g RFP are both consonant with the Higuchi diffusion release model,but the former is more consonant.

关 键 词：磷酸八钙骨水泥 药物载体 缓释 

分 类 号：TB3[一般工业技术—材料科学与工程] TQ026.8[化学工程]