脂脉康颗粒治疗高脂血症(痰浊阻遏证)临床观察  

Clinical Observation on the Curative Effect of Zhimaikang Granules on Hyperlipidemia-Syndrome of Turbid Phlegm Obstructin

作　　者：李典鸿[1] 王清海[1] 靳利利[1] 黄培红[1] 袁丁[1] 苏慧[1] 

机构地区：[1]广东省第二中医院,广东广州510095

出　　处：《深圳中西医结合杂志》2011年第3期139-142,共4页Shenzhen Journal of Integrated Traditional Chinese and Western Medicine

基　　金：广东省中医药管理局立项课题(103087)

摘　　要：目的:通过应用脂脉康颗粒治疗血脂异常(痰浊阻遏型)的临床研究,观察本方调脂(降脂)的临床疗效,探索临床治疗血脂异常的有效方法。方法:将120例血脂异常患者随机分为治疗组和对照组,每组各60例。治疗组予脂脉康颗粒,每次1包,每日2次,饭前服用。对照组予舒降之20mg每晚1次。两组均以45d为1疗程。结果:①中医证候疗效比较:治疗组在改善中医证候方面优于对照组。②实验室检查疗效比较:两组相比无显著性差异(P>0.05),说明两药在改善血脂方面均有较好的疗效。③治疗前后两组症状、中医证候积分改善的疗效比较:两组患者治疗后证候均明显改善,且治疗组改善优于对照组。④治疗前后两组血脂改善的疗效比较:治疗组在降血清TC、AI含量及TC/HDL-C比值方面与对照组基本相同;降血清TG则优于对照组(P<0.05);而对照组对LDL-C的疗效较好;两组对HDL-C的疗效均不显著。⑤治疗前后两组血液流变学改善的疗效比较:两组病例治疗前后比较,全血黏度(低切、高切)、红细胞压积、纤维蛋白原均显著降低。结论:脂脉康颗粒治疗血脂异常的疗效确切,与对照组西药相比能显著减少临床症状和体征,无毒副作用,近期疗效可靠,是为治疗血脂异常的有效方剂之一。Objective To observe the curative effect of Zhimaikang Granules on hyperlipidemia-syndrome of turbid phlegm obstructin,and explore an effective lipid-lowering treatment for Dyslipidemia.Methods 120 patients with dyslipidemia were randomly divided into treatment group and control group,60 cases in each group.The treatment group was given Zhimaikang Granules before meals,1 bag every times,two times per day.The control group was given Zocor（Simvastatin Tablets） 20mg Qn.Patients in both groups were treated for 45 days as one course of treatment.Results ①Comparison of TCM syndromes：The treatment group was better than the control group in improving TCM syndromes.② Comparison of laboratory tests of curative effect：There was no obvious difference between two groups（P 0.05）.The result showed that two drugs both had a better effect on improving hyperlipidemia.③Comparison of symptoms before and after treatment,improving efficacy of symptom scores：Both groups showed obvious improving efficacy of symptom scores after treatment,and the treatment group was better than the control group.④Comparison of lipid-lowering efficacy between two groups after treatment：There was no significant difference in decreasing the serum total cholesterol（TC）,AI content and TC/HDL-C ratio between two groups.The treatment group significantly decreased the serum triglyeride（TG） content（P 0.05）,comparing with the control group.But the control group had a better efficacy in decreasing the serum low-density lipoprotein（LDL-C） level.There was no obvious effect in improving high-density lipoprotein（HDL-C） level in both two groups.⑤Comparison of the curative efficacy in hemorrheology improvement：The whole blood viscosity（low shear,high shear）,hematocrit,and fibrinogen were all markedly lowered after treatment in two groups.Conclusion Zhimaikang Granules is effective on dyslipidemia therapy.It can singnificantly improve the clinical syndrome and sign with no toxicity and side effects,and has a reliable eff

关 键 词：脂脉康颗粒 疗效 高脂血症 

分 类 号：R589.2[医药卫生—内分泌]