连萸总生物碱胃滞留双室渗透泵片的制备及体外释放度考察  

Studies on Preparation and Dissolution Test in vitro of Intragastric Floating Two-chamber Osmotic Pump Tablets of Total Alkaloids of Coptis chinensis and Evodia rutaecarpa

作　　者：方瑜[1] 史清文[1] 

机构地区：[1]河北医科大学药学院,河北石家庄050017

出　　处：《中药材》2011年第5期779-782,共4页Journal of Chinese Medicinal Materials

摘　　要：目的:对连萸总生物碱胃滞留双室渗透泵片(TCOPT)的制备方法进行研究,并考察其体外释放度。方法:以释放度为评价指标,采用正交设计实验优化处方与工艺。结果:最佳处方为:膨胀剂为PEO(Mw 5000000)与HPMC混合物(4∶1),用量50 mg,助推层渗透剂氯化钠用量为20 mg,包衣液致孔剂PEG 400用量10%,包衣增重9%。释药行为符合零级方程,具有明显的控释特征。结论:TCOPT具有良好的体外控释效果,可进一步进行体内释药行为考察。Objective：To study prescription and technique of intragastric floating two-chamber osmotic pump tablets（TCOPT）of total alkaloids of Coptis chinensis and Evodia rutaecarpa and inspect release property in vitro.Methods：The orthogonal experiment was designed to screen prescription and technique.Results：The optimization of prescription and technique were as follows：the expanding agent was a mixture of PEO and HPMC as a ratio of 4∶1;the osmotic agent in propelling layer contained sodium chloride 20 mg,PEG 400 in the cellulose acetate,10%;coating membrane in core tablet,9%.The release behavior of TCOPT coincidented with zero-level equation well and the character of controlled-release was transparent.Conclusion：TCOPT has good effect of controlled-release in vitro and the release behavior in vivo need to be inspected.

关 键 词：黄连 吴茱萸 双室渗透泵片 胃滞留 体外释放 

分 类 号：R944.2[医药卫生—药剂学]