Investigation of Reaction Mechanism of Amino Acids and Phosphorus Trichloride by 31P NMR and ESI-MS/MS  

作　　者：Guo, Yanchun Cao Shuxia Xie, Yali Zong, Xiangkun Zhao, Yufen 

机构地区：[1]Key Laboratory of Chemical Biology and Organic Chemistry, Department of Chemistry, Zhengzhou University, Zhengzhou, Henan 450052, China [2]College of Chemistry and Chemical Engineering and The Key Laboratory for Chemical Biology of Fujian Province, Xiamen University, Xiamen, Fujian 361005, China [3]Key Laboratory for Bioorganic Phosphorus Chemistry of Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China

出　　处：《Chinese Journal of Chemistry》2011年第6期1173-1179,共7页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20672104, 20732004）

摘　　要：The reaction of amino acids and phosphorus trichloride in THF was studied by 31P NMR tracing and ESI-MS/MS. A series of hydridophoranes and cyclic dipeptides were obtained. The reaction presented interesting diversity and the reaction mechanism was proposed. The mechanism suggests that phosphorus plays an important role in the synthesis of amino acid hydridophorane and cyclic dipeptides. The results also show that 31P NMR and ESI-MS/MS are useful tools for the investigation of reaction mechanism.The reaction of amino acids and phosphorus trichloride in THF was studied by 31P NMR tracing and ESI-MS/MS. A series of hydridophoranes and cyclic dipeptides were obtained. The reaction presented interesting diversity and the reaction mechanism was proposed. The mechanism suggests that phosphorus plays an important role in the synthesis of amino acid hydridophorane and cyclic dipeptides. The results also show that 31P NMR and ESI-MS/MS are useful tools for the investigation of reaction mechanism.

关 键 词：31P NMR ESI-MS/MS MECHANISM amino acid phosphorus trichloride 

分 类 号：O482.532[理学—固体物理] TS255.44[理学—物理]