Synthesis of 1-Aryl-1 H-indazoles via a Ligand-Free Copper- Catalyzed Intramolecular Amination Reaction  

作　　者：Gao, Mingshan Liu, Xiujie Wang, Xianyang Cai, Qian Ding, Ke 

机构地区：[1]Key Laboratory of Regenerative Biology and Institue of Chemical Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, Guangdong 510530, China [2]Jiangsu Provincial Institute of Materia Medica, Nanjing University of Technology, Nanjing, Jiangsu 210009, China

出　　处：《Chinese Journal of Chemistry》2011年第6期1199-1204,共6页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China＇（Nol 21002102）, and State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences （No. 10184）.

摘　　要：A general synthesis of 1-aryl-l-H-indazoles from o-halogenated aryl aldehydes or ketones and aryl hydrazines was described. This protocol included an intermolecular condensation and a ligand-free copper-catalyzed intramolecular Ullmann-type coupling reaction. This method was applied to a wide range of substrates to produce the indazole products in good yields.A general synthesis of 1-aryl-l-H-indazoles from o-halogenated aryl aldehydes or ketones and aryl hydrazines was described. This protocol included an intermolecular condensation and a ligand-free copper-catalyzed intramolecular Ullmann-type coupling reaction. This method was applied to a wide range of substrates to produce the indazole products in good yields.

关 键 词：COPPER AMINATION ligand free 

分 类 号：TQ226.31[化学工程—有机化工] TB333[一般工业技术—材料科学与工程]