放射性碘治疗Graves病后早发甲状腺功能减退症相关因素的调查  

Related factors in predicting hypothyroidism of Graves disease after 131I therapy

作　　者：王娟娟[1] 付怀云[1] 王青平[1] 许瑞霞[1] 殷丽[1] 

机构地区：[1]山西省地方病防治研究所附属医院核医学科,山西省临汾市,041000

出　　处：《中国医药》2011年第7期798-799,共2页China Medicine

摘　　要：目的 探讨放射性碘治疗Graves病导致早发甲状腺功能减退症（甲减）的可能因素.方法 对260例行131I治疗的Graves病患者进行随访研究,将1年随访期内诊断为早发甲减者纳入早发甲减组,其余纳入对照组.采用病例对照研究的方法,对2组患者的性别、年龄、甲状腺估重、摄碘功能、服用放射性药物情况等进行对比研究,探讨导致早发甲减的可能因素.结果 早发甲减组36例,对照组212例,失访12例.根据甲状腺质量进行分级处理,早发甲减组与对照组甲状腺质量间的差异无统计学意义（u=1.589,P〉0.05）.早发甲减组与对照组131I转换率间的差异存在统计学意义（0.66±0.19比0.79±0.21,t=2.712,P〈0.01）.早发甲减组与对照组每克甲状腺给予131I活度（100μCi比90μCi）间的差异存在统计学意义（u=2.144,P〈0.05）.结论 转换率和每克甲状腺给予的131I活度是影响早发甲减发生的因素.Objective To explore the factors of predicting outcome of Graves disease after 131I therapy.Methods Two hundred and sixty patients with Graves disease were given 131I therapy and then were followed up for a year.Thirty six patients of early hypothyroidism were therapy group.Using case-control study method,gender,age,goiter size,radioactive iodine uptake,dose of 131I therapy and desired dose per gram of thyroid were compared between the early hypothyroidism group and control group to explore the value factor in predeting early hypithyroidism.Results Goiter size of patients of early hypothyroidism Was similar（μ=1.59,P〉0.05）when thyroid were divided into Ⅰ,Ⅱ and Ⅲ degree by thyroid size.131I turnover rate of early hypothyroidism（0.66±0.19,0.79±0.21） wsa significanly lower than that in controlgroup（t=2.712,P〈0.05）.Desired dose per gram of thyroid of early hypothyroidism group were significantly higher than dose of patients of control group（u=2.144,P〈0.05）.Conclusion 131 I turnover rate and desired dose per gram of thyroid are two effective prognostic markers of early hypothyroidism.

关 键 词：Graves病 早发甲状腺功能减退症 131I治疗 吸碘率 

分 类 号：R581.1[医药卫生—内分泌]