蟾酥对豚鼠心脏电生理的影响  

Toxic effect of Chansu on cardiac electrophysiology in guinea-pigs

作　　者：蒋洁君[1] 周婧[1] 马宏跃[1] 吕高虹[1] 喻斌[1] 段金廒[1] 张军峰[1] 詹瑧 许惠琴[1] 

机构地区：[1]南京中医药大学药学院江苏省方剂研究重点实验室,江苏南京210046

出　　处：《中国药理学与毒理学杂志》2011年第3期307-309,共3页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金青年科学基金(30901894);教育部博士点基金新教师类(20093237120013),教育部霍英东教育基金会第十二届青年教师基金(121044);江苏省中医药局科技项目(LZ09017)~~

摘　　要：目的探讨蟾酥对豚鼠心脏的急性毒性。方法豚鼠一次性ig给予蟾酥125和250 mg·kg-1,记录心电图并监测左心室内压力上升最大速率(dp/dtmax),最大收缩压(Pmax),心率血压乘积(RPP)和心室最小舒张压(Pmin)。结果蟾酥使豚鼠心电图发生显著改变;与正常对照组P-R间期(27.8±5.1)ms相比,蟾酥125和250 mg·kg-1组显著延长,分别为44.5±7.2和(57.1±8.9)ms(P<0.01);蟾酥也引起心电图QRS时程增宽和心率加快;dp/dtmax,Pmax和RPP显著下降以及Pmin显著升高(P<0.05)。与阳性对照地高辛300mg·kg-1相比,蟾酥组P-R间期,QRS时程,dp/dtmax,Pmax,RPP和Pmin无显著性差异,但心率显著增快(P<0.01)。结论蟾酥导致豚鼠心律失常和心功能下降。OBJECTIVE To study the effect of Chansu（toad venom,Venenum Bufonis） on the cardiac electrical activity and function.METHODS After guinea-pigs were ig given a single dose of Chansu 125 and 250 mg·kg^-1,electrocardiography and cardiac function were monitored.The cardiac function was evaluated by measuring the maximum rate of rise of left ventricular pressure（dp/dtmax）,the maximum systolic pressure（Pmax）,rate-pressure product（RPP）and the minimum diastolic pressure（Pmin）.RESULTS Compared with normal control group,the P-R interval in Chansu 150 and 250 mg·kg^-1 groups significantly increased from（27.8±5.1） ms to 44.5±7.2 and（57.1±8.9）ms（P〈0.01）.Chansu also induced wide QRS complex and rapid heart rate,markedly increased Pmin（P〈0.05）,but decreased Pmax,RPP and dp/dtmax（P〈0.05）.No significant difference in P-R interval,QRS complex,dp/dtmax,Pmax,RPP and Pmin was observed between Chansu and digoxin 300 mg·kg^-1,but Chansu induced faster heart rate than digoxin.CONCLUSION Chansu poisoning can induce arrhythmias and cardiac dysfunction.

关 键 词：蟾酥 心脏毒性 心律失常 心功能 

分 类 号：R285.5[医药卫生—中药学]