楂芪降糖汤对实验性糖尿病大鼠血糖及氧化应激的影响  

Effects of Zhaqi Jiangtang Decoction on Blood Glucose and Oxidative Stress in Diabetic Rats

作　　者：李进[1] 黄学宽[1] 任凌燕[2] 沈清[1] 

机构地区：[1]重庆医科大学中医药学院,重庆401331 [2]重庆科技学院化学化工学院,重庆401331

出　　处：《中国实验方剂学杂志》2011年第13期124-126,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：重庆市卫生局科技项目(2005-B-36)

摘　　要：目的:研究楂芪降糖汤对糖尿病大鼠血糖及氧化应激的影响。方法:链脲佐菌素(STZ)腹腔注射诱导糖尿病大鼠模型,造模成功后分别以楂芪降糖汤(5.5,11,22 g·kg-1)、优降糖(5×10-3 g·kg-1)ig。治疗4周后,进行空腹血糖及抗氧化指标的检测。结果:与正常对照组比较,模型组大鼠空腹血糖(FBG)、血清丙二醛(MDA)含量明显升高,血清过氧化氢酶(CAT)、超氧化物歧化酶(SOD)活性则明显降低(P<0.05),而楂芪降糖汤可以降低糖尿病大鼠FBG及MDA的含量,还可提高其血清CAT,SOD的活性(P<0.05)。结论:楂芪降糖汤具有明显降糖作用,其作用机制可能与降低氧化应激水平有关。Objective：To investigate the effects of Zhaqi Jiangtang Decoction on blood glucose and oxidative stress in diabetic rats.Method：The mode1 rats of diabetes were made by injection STZ into the abdominal cavity.After the model formed,the rats with diabetes were treated with Zhaqi Jiangtang Decoction,Youjiangtang through gastric feeding.The treatment lasted for 4 weeks,the influence on fasting blood glucose（FBG）,superoxide dismutase（SOD）,catalase（CAT）maleicdialdehyde（MDA）for treated rats with diabetes was observed.Result： The levels of FBG and SOD were increased significantly,and the levels of CAT and SOD reduced significantly in the blood serum of the model rats compared to the normal group（P0.05）;Zhaqi Jiangtang Decoction could not only reduce the 1evers of FBG and MDA,but also rise the 1evels of CAT and SOD in the model rats（P0.05）.Conclusion：Zhaqi Jiangtang Decoction has obvious effect to reduce the blood glucose and its mechanism may be related to inhibition of oxidative stress in diabetic rats.

关 键 词：楂芪降糖汤 糖尿病 血糖 氧化应激 

分 类 号：R285.5[医药卫生—中药学]