梅花钻对乙醇引起小鼠肝损伤的保护作用  

Protective Effect of Kadsura heteroclite on Ethanol-induced Hepatotoxicity in Mice

作　　者：韦健全[1] 罗莹[1] 薛强[1] 潘勇[1] 郑子敏[1] 

机构地区：[1]右江民族医学院药理学教研室,广西百色533000

出　　处：《中国实验方剂学杂志》2011年第13期167-169,共3页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：广西壮族自治区教育厅立项课题(桂教科研【2006】26号;右医科字【2007】2号)

摘　　要：目的:研究梅花钻对乙醇引起肝损伤的保护作用。方法:将昆明种小鼠分为正常对照组、乙醇模型组、梅花钻(33.40,16.70,8.35 g·kg-1)剂量组,观察各组小鼠血清的丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、谷胱甘肽S-转移酶(GST)、超氧化物歧化酶(SOD)活性和肝匀浆中的丙二醛(MDA)、甘油三酯(TG)的含量,评价梅花钻对肝损伤的保护作用。结果:梅花钻高、中剂量组与乙醇模型组比较,ALT,AST,GST,MDA,TG降低(P<0.05或P<0.01),SOD明显升高(P<0.01)。结论:梅花钻对小鼠乙醇引起的肝损伤有保护作用。Objective：To study the protective effect of Kadsura heteroclita（Roxb）Craib（KHC）on ethanol-induced hepatotoxicity in mice.Method： Mice were randomly divided into 5 groups to set up the model of hepatotoxicity by ethanol in mice：the normal,the ethanol model and 3 groups of KHC（33.40,16.70,8.35 g·kg-1）.The activities of alanine transaminase（ALT）,aspartate transaminase（AST）,glutathione s-transferase（GST）,superoxide dismutase（SOD）in serum and the contents of malondialdehyde（MDA）,triglyceride（TG）in liver were measured.Result： KHC（33.40,16.70 g·kg-1,qd×7）could reverse the activities of serum ALT,AST,GST,SOD and could decrease the contents of MDA,TG in liver.Conclusion： KHC showed effective protection on ethanol-induced hepatotoxicity.

关 键 词：梅花钻 乙醇 肝损伤 谷胱甘肽S-转移酶 丙二醛 

分 类 号：R285.5[医药卫生—中药学]