固相有机合成中钯催化的交叉偶联反应研究进展  

Research Progress of Pd Catalyzed Cross-coupling Reactions Utilized in Solid Phase Organic Synthesis

作　　者：郝树林[1,2] 张政朴[1] 刘长令[2] 

机构地区：[1]南开大学高分子化学研究所,吸附分离功能高分子材料教育部重点实验室,天津300071 [2]沈阳化工研究院有限公司,新农药创制与开发国家重点实验室,沈阳110021

出　　处：《高分子通报》2011年第7期1-23,共23页Polymer Bulletin

摘　　要：过渡金属钯催化交叉偶联反应是形成碳—碳键的一种十分有效的方法,因此钯催化的C—C偶联反应引起了更多人们的广泛关注,并发展了多种不同的C—C偶联反应,包括Heck反应、Negishi反应、Suzuki偶联和Stille偶联等。固相有机合成具有反应条件温和、可使多种活性官能团兼容、受空间位阻影响小、具有高度的化学选择性、毒性小、副产物少且易于分离纯化、产率高等优点,近几年来一直是催化化学和固相合成与组合化学的研究热点。本文根据不同的分类标准结合本课题组的研究工作综述了近年来人们对Heck反应、Negishi反应、Suzuki偶联和Stille偶联在固相有机合成中钯催化交叉偶联反应的研究进展,最后展望了固相合成中钯催化交叉偶联反应的研究前景。Coupling reaction using transition metal Pd as catalyst has been very efficient in formulating C-C bond,thus Pd catalyzed C-C coupling reaction has been under spotlight of scientists＇ attention for years and series of derivative reactions were thence developed, among which Pd catalyzed Solid-phase organic reactions suck as Heck reaction, Negishi reaction, Suzuki coupling and Stille coupling,with their accessible reaction conditions, high tolerance of diverse functional groups,low steric hindrance, excellent chemical selectivity, mild toxicity, side products friendly and removable, efficient in yields, have always been the researching focus of catalytic chemistry and solid phase combinatory chemistry. With reference to different classification standards and our own research work, this article reviews the researching progresses of Pd catalized Cross-coupling reactions used in solid phase organic synthesis reactions,such as Heck/Negishi/Suzuki and Stille reaction.

关 键 词：钯催化 偶联反应 HECK反应 Negishi反应 SUZUKI偶联 Stille偶联 固相合成与组合化学 

分 类 号：O643.32[理学—物理化学]