大分子对磁共振造影剂配体改性的研究进展  

Progress in MRI Contrast Agent Ligands Modified by Macromolecules

作　　者：梁晟斌[1] 常飞[1] 李建奇[2] 李欣欣[3] 宋春梅[1,2] 

机构地区：[1]化学系华东师范大学,上海200062 [2]上海市磁共振重点实验室华东师范大学,上海200062 [3]华东理工大学材料学院,上海200237

出　　处：《高分子通报》2011年第7期96-102,共7页Polymer Bulletin

基　　金：国家高科技研究发展计划(863计划,2004AA302080);上海市项目48100270;上海市磁共振重点实验室(华东师范大学)开放课题基金资助

摘　　要：磁共振成像造影剂是一种信号增强剂,在临床上已有广泛应用。本文介绍了磁共振造影剂配体的种类、结构、改性研究情况和发展趋势,并通过弛豫理论解释合成大分子配体的原因。将含有大分子、靶向性、天然大分子、荧光探针的配体与顺磁性金属Gd(Ⅲ)螯合,制得功能磁共振造影剂,可有效增加弛豫效果和降低生物毒性。Magnetic resonance imaging （MRI） contrast agents are used widely in clinical use. The advantage of macromolecular contrast agents was explained by relaxation theory. The chemical structures and development of the contrast agents were also introduced in this review. The paramagnetic Gadolinium （Ⅲ） chelates were modified by synthetic polymers, naturally occurring polymers, targeted agents and fluorescent labeled agents. It is indicated that the specific effects of modified contrast agents such as targeting and florescent labeled would raise the relaxation rate and reduce the toxicity.

关 键 词：造影剂 磁共振 弛豫理论 荧光探针 大分子配体 靶向性 

分 类 号：TQ421.7[化学工程]