多站式法诊断早期宫颈疾病的临床价值  

Combined use of three methods for detection of cervical diseases at early stage

作　　者：李书卫[1] 陈曼玲[1] 张峻霄[1] 陈雪银[1] 金松[1] 

机构地区：[1]海南医学院附属医院妇产科,海南海口570102

出　　处：《海南医学院学报》2011年第7期907-909,共3页Journal of Hainan Medical University

基　　金：海南省卫生厅科研基金资助项目(2007-49)~~

摘　　要：目的:评价液基细胞学(TCT)、高危型人乳头状瘤病毒(HR-HPV)检测及阴道镜下宫颈病理学检查对早期宫颈疾病的临床诊断价值。方法:320例TCT检查异常的患者,同时行第二代杂交捕获(HC-Ⅱ)检测HR-HPV及阴道镜检查,并取宫颈组织行病理学诊断。结果:宫颈组织学检查细胞阳性率明显高于TCT(P<0.01);阴道镜下宫颈病理学检查可降低HR-HPV检测的漏诊率;随宫颈细胞学检查级别增加,HPV感染发生率增加(P<0.01),CIN发生率增加(P<0.01),宫颈病理学诊断HPV感染发生率增加(P<0.01)。TCT、HR-HPV检测联合阴道下宫颈病理学检查阳性率可达100.0%。结论:TCT、HR-HPV检测联合阴道镜下宫颈病理学检查是子宫颈疾病早期诊断重要的辅助手段,三者相结合可提高宫颈早期疾病的检出率。Objective： To evaluate the predictive value of liquid-based cervical cytology（TCT）,high-risk human papilloma virus（HR-HPV） detection and vaginal microscopically cervical pathological examination in diagnosis of cervical lesions.Methods： A total of 320 patients that showed abnormal TCT results underwent HR– HPV detection,vaginal endoscopy examination and pathological examinataion.Results：（1） Histological examination showed significant higher positive rate of the cervical diseases than TCT（P〈0.01）.（2）Vaginal microscopically cervical pathological examination can reveal more HR-HPV.（3） With increase of cervical cytology levels,the rate of HPV infection and CIN incidence increased;HPV infection revealed by cervix pathology examination also increased.The positive rate of joint TCT,HR-HPV testing and vaginal microscopically cervical pathological examination can be as high as 100%.Conclusions： Combined use of TCT,HR-HPV testing and vaginal microscopically cervical pathology examination is an important auxiliary method for detection of cervical diseases at early stage since it can raise the diagnostic accuracy.

关 键 词：液基细胞学 高危型人乳头状瘤病毒 阴道镜 宫颈病理学检查 早期宫颈疾病 

分 类 号：R711.74[医药卫生—妇产科学]