持续应用小剂量氨茶碱治疗早产儿原发性呼吸暂停的临床观察  

Effect of continuous application of aminophylline at low dosage on primary apnea in premature infants

作　　者：李岚芳 

机构地区：[1]湖北省赤壁市人民医院儿科新生儿室,湖北赤壁437300

出　　处：《海南医学院学报》2011年第7期977-978,982,共3页Journal of Hainan Medical University

基　　金：海南医学院科研基金资助学报项目(0020110250)~~

摘　　要：目的:探讨持续小剂量氨茶碱对早产儿原发性呼吸暂停的治疗效果。方法:2005年～2009年收治的原发性呼吸暂停早产儿共72例,2007年前36例为对照组,2007年～2009年36例为实验组。两组在发生呼吸暂停后每次静滴氨茶碱5 mg/kg。实验组12 h后每次给维持量2.5 mg/kg;对照组不使用氨茶碱维持治疗。观察两组在生后一周内呼吸暂停的发生率、平均用氧时间、需机械通气百分率、每日体重增长及住院时间。结果:实验组在呼吸暂停的发生率、平均用氧时间、需机械通气百分率、住院时间均明显低于对照组,每日体重增长高于对照组,两组比较差异有统计学意义(P<0.05)。结论:持续应用小剂量氨茶碱治疗早产儿原发性呼吸暂停有效,安全剂量范围内无明显不良反应,值得推广应用。Objective： To discuss effect of continuous application of aminophylline at low dosage on primary apnea in premature infants.Methods： A total of 72 premature infants with primary apnea admitted from 2005-2009 were selected and randomly divided into experimental group and control group by half.They were treated by venous injection of aminophylline 5 mg/kg.After 12 h,the dosage in experiment group was maintained at 2.5 mg/kg,while the treatment was quitted in control group.The incidence of apnea,average time for oxygen using,percentage of mechanical ventilation,increase of weight every day and hospitalization time were observed and compared.Results： The incidence of apnea,average time for oxygen using,percentage of mechanical ventilation and hospitalization time were significantly lower,and the weight was significantly increased in experiment group（P〈0.05）.Conclusions： Continuous application of aminophylline at low dosage is effective and without remarkable side effect.It is worthy extensive application.

关 键 词：早产儿 原发性呼吸暂停 氨茶碱 

分 类 号：R722.6[医药卫生—儿科]