乌司他丁对剖宫产患者凝血及血小板聚集功能的影响  

Effect of ulinastatin on coagulation and platelet aggregation in cesarean section

作　　者：赵若光[1] 陈彦青[1] 姚玉笙[1] 陈晓辉[1] 

机构地区：[1]福建省立医院麻醉科,福州市350001

出　　处：《临床麻醉学杂志》2011年第6期566-568,共3页Journal of Clinical Anesthesiology

摘　　要：目的观察乌司他丁对剖宫产患者术中凝血及血小板聚集功能的影响。方法选择60例无血液疾病及凝血功能障碍、肝肾功能异常或服用相应药物的择期剖宫产患者,ASAⅠ或Ⅱ级,随机均分为乌司他丁组和生理盐水组。分别于胎儿娩出后给药前(T0)、给药后1 h(T1)、2 h(T2)、4 h(T3)采血测定凝血酶原时间(PT)、部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)、国际标准化比率(INR)及血小板1 min,5 min聚集率及最大聚集率(PAG1、PAG5、PAGM)。结果与T0时比较,乌司他丁组T1时PT、APTT延长(P<0.05);T2时TT延长(P<0.05)。与生理盐水组比较,乌司他丁组T1时APTT、T2时TT延长(P<0.05)。两组PAG1、PAG5、PAGM组内及组间比较差异均无统计学意义。结论围术期静脉滴注乌司他丁5 000 U/kg可改善剖宫产患者术中的高凝血状态,有助于预防术后深静脉血栓形成。Objective To evaluate the efficacy of ulinastatin（UTI） on coagulation and platelet aggregation in cesarean section. Methods Sixty ASA Ⅰ or Ⅱ patients scheduled for selective cesarean section under spinal anesthesia were enrolled in this study. Patients were allocated to receive either UTI 5 000 U/kg （UTI group, n=30） or normal saline （control group, n=30）. PT, TT, APTT, FIB, INR and PAG1, PAG5 and PAGM were measured before delivery （T0）, 1 h （T1）, 2 h （T2） and 4 h after UT! infusion （T4）. Results Compared with To ,PT,APTT and TT in UTI group were prolonged significantly at T1 and T2, respectively. Compared with the control group, APTT and TT in UTI group were prolonged significantly at T1 and T2, respectively. There was no difference of PAG1, PAGS, PAGM between two groups. Conclusion UTI 5 000 U/kg can improve hypercoagulative status, which may reduce the risk of thrombosis during and after the operation.

关 键 词：胰蛋白酶抑制剂 血小板聚集 凝血功能 外科手术 

分 类 号：R719.8[医药卫生—妇产科学]