银屑病性关节炎患者血清中转化生长因子-β1的检测  

Measurement of transforming growth factor （TGF）-β1 in sera of patients with psoriatic arthritis

作　　者：杨雁[2] 杨静[3] 段西凌[2] 李薇[1] 

机构地区：[1]四川大学华西医院皮肤科,成都610064 [2]四川省人民医院皮肤性病研究所 [3]四川省人民医院临床检验中心

出　　处：《中华皮肤科杂志》2011年第7期513-514,共2页Chinese Journal of Dermatology

基　　金：四川省卫生厅科研基金（303005002154013）

摘　　要：目的探讨银屑病性关节炎患者血清中转化生长因子（TGF）-β1的表达及其意义。方法分别检测银屑病性关节炎患者与寻常性银屑病患者血清中TGF-β1的水平。结果38例银屑病性关节炎患者血清中的TGF-β1浓度为375．92±95．88pg／ml，80例寻常性银屑病患者为510．78±167．97pg／ml，两组差异有统计学意义（t=4．60，P〈0．01）。结论对银屑病性关节炎患者进行血清TGF-β1浓度的动态监测，有助于引起临床医师对银屑病性关节炎骨质疏松的警惕和预防。Objective To measure the expression of TGF-β1 in the sera of patients with psoriatic arthritis and its significance. Methods The serum level of TGF-β1 was measured in 38 patients with psoriatic arthritis and 80 patients with psoriasis vulgaris. Results A significant difference was observed between the patients with psoriatic arthritis and those with psoriasis vulgaris （375.92 ± 95.883 pg/ml vs. 510.78 ±167.967 pg/ml, t = 4.60, P 〈 0.01）. Conclusion Continuous monitoring of serum levels of TGF-β1 may help clinicians to take precautions against osteoporosis in patients with psoriatic arthritis.

关 键 词：血清TGF-Β1 转化生长因子-Β1 银屑病性关节炎 关节炎患者 检测 银屑病患者 动态监测 骨质疏松 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]