穿心莲内酯微乳在大鼠体内的吸收机理研究  

Absorption mechanism of andrographolide microemulsion in rats

作　　者：杜红[1] 李海燕[1] 徐荣廷[1] 牛欣[1] 冯前进[2] 

机构地区：[1]北京中医药大学,北京100029 [2]山西中医学院

出　　处：《北京中医药大学学报》2011年第6期384-386,共3页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家"十五"科技攻关课题资助项目(No.2004BA721A46)

摘　　要：目的以穿心莲内酯微乳为对象,探讨微乳制剂的吸收机理及影响吸收的因素。方法采用大鼠原位灌注实验法,探讨载体抑制剂、能量抑制剂、P-糖蛋白抑制剂对穿心莲内酯微乳在大鼠小肠内吸收行为的影响。结果穿心莲内酯微乳在小肠的吸收需要载体;受到P-糖蛋白外排作用的影响;可能不耗能。结论微乳制剂在小肠中可能存在被动转运和淋巴吸收2种吸收机理。Objective To investigate the absorption mechanism taken andrographolide microemulsion as the object. Methods and the factors influencing the absorption The test of in situ perfusion was used for studying the influences of carrier inhibitor, energy inhibitor and P-glycoprotein inhibitor on the absorption behavior of andrographolide microemulsion in rat small intestine. Results The absorption of andrographolide microemulsion needed carrier in the small intestine, and which was influenced by the exocytosis of P-glycoprotein and might have no energy consumption. Conclusion There may be two absorption mechanisms of microemulsion in the small intestine, one is passive transportation and the other is lymphatic absorption.

关 键 词：穿心莲内酯 微乳 吸收 机理 原位灌注法 大鼠 

分 类 号：R285.5[医药卫生—中药学]