一线主要抗结核药不良反应分布特点文献分析  

Literature Analysis on the Characteristic of Distribution of Adverse Drug Reactions Induced by Main First-line Antituberculosis Drugs

作　　者：石富国[1] 古明[1] 马世平[1] 

机构地区：[1]中国药科大学,江苏南京210009

出　　处：《中国药物警戒》2011年第7期434-437,共4页Chinese Journal of Pharmacovigilance

基　　金：江苏省高等学校数字图书馆三期工程资助项目中国药物不良反应信息数据库(项目编号J:S2008-21)

摘　　要：目的探讨一线主要抗结核药不良反应的分布特点,为临床合理安全用药提供参考。方法对1989年1月至2009年12月发表的文献进行全面检索,对4种主要一线药物(异烟肼、利福平、乙胺丁醇、吡嗪酰胺)所致不良反应的发生时间分布,病例的年龄和性别分布,个药所致的不良反应累及的系统-器官进行统计,并分析个药致不良反应的特点以及影响因素等。结果共统计整理病例739例,男性437例,女性299例,性别不详3例;出现不良反应时间最短的为2分钟,最迟的为50年。抗结核药的不良反应主要累及神经、泌尿、血液等12个系统,多发不良反应包括急性肾功能衰竭、药物肝损伤、过敏性紫癜、过敏性休克、视神经炎等。结论临床应高度重视抗结核药不良反应的分布规律和特点,确保安全合理用药。Objective To investigate the characteristics of distribution of adverse drug reaction induced by first-line antituberculosis drugs and to provide reference for clinical safety and proper administration.Methods The literature between January 1989 and December 2009 was retrieved.For four first-line drugs（isoniazid,rifampin,ethambutol,pyrazinamide）,the time of occurrence of adverse reactions,age and gender distribution of cases and systems or system-organs related adverse reactions caused by individual drug were counted up,the characteristics and factors involved in individual adverse reactions were also analyzed.Results The total of 739 cases were collected,437 in male,299 in female,and 3 cases with unknown sex.Ages ranged from 3 months to 82 years old.The shortest time of occurrence of adverse reaction was 2 min and the longest about 50 years.The adverse reactions of antituberculosis drugs were widely distributed in 12 systems,such as the nervous system,urinary system,and hematological system and so on.Multiple adverse reactions included acute renal failure,drug-induced hepatic injury,anaphylactoid purpura,anaphylactic shock,optic neuritis and so on.Conclusion More attention should be paid to the characteristics and rule of distribution of adverse drug reaction of antituberculosis drugs induced in clinical and to ensure safety and proper administration.

关 键 词：抗结核药 药品不良反应 文献分析 

分 类 号：R978.3[医药卫生—药品] R994.11[医药卫生—药学]