3-甲基噻吩自由基溴化反应研究  

Investigation on radical bromination of 3-Methylthiophene

作　　者：王娟[1] 王春英[1] 赵立娟[1] 王萍[1] 刘福德[1] 

机构地区：[1]天津理工大学化学化工学院,天津300384

出　　处：《天津理工大学学报》2011年第3期67-69,共3页Journal of Tianjin University of Technology

摘　　要：研究了以3-甲基噻吩、NBS为原料的光引发及化学引发自由基溴化反应,发现光引发方法在低于25℃时只生成3-甲基-2-溴噻吩.L9(34)正交实验表明,化学引发方法在70℃、反应时间为3 h、3-甲基噻吩和NBS的摩尔比为0.9∶1时,3-溴甲基噻吩选择性最高,为52.4%.Radical bromination of 3-methylthiophene with NBS by photoinition and AIBN inition has been investigated.It shows that when reaction temperature is less than 25 ℃ only 3-methyl-2-bromothiophene is synthesized by photoinition.Orthogonal experiment shows that when initiator is AIBN and reaction temperature is 70 ℃,reaction time is 3h,the ratio of 3-methylthiophene to NBS is 0.9∶ 1,the selectivity of 3-bromomethylthiophene is 52.4%.

关 键 词：3-甲基噻吩 3-溴甲基噻吩 自由基溴化 2-溴-3-甲基噻吩 

分 类 号：O621.3[理学—有机化学]