N,N′-二烷基撑基环脲类化合物的合成工艺研究  

Studies on synthesis of N,N′-dialkylalkyleneureas

作　　者：韩斌[1] 尹宁[1] 毛桂红 邹良库[1] 卢俊瑞[1] 

机构地区：[1]天津理工大学化学化工学院,天津300384 [2]天津久日化学工业有限公司,天津300185

出　　处：《天津理工大学学报》2011年第3期76-80,共5页Journal of Tianjin University of Technology

摘　　要：N,N′-二烷撑基环脲类化合物做为一种新型的多功能溶剂已得到了广泛应用.本工艺以烷基二胺、尿素为原料,经环合和N-烷基化绿色高效制备了1,3-二甲基-2-咪唑酮(DMEU或DM I)、1,3-二甲基-2-嘧啶酮(DMPU),收率分别为74.5%和75.6%,并对目标化合物进行了表征.该工艺已顺利完成了1 000 L反应釜的中试.从而建立了高效、通用、绿色的N,N′-二烷撑基环脲类化合物的合成工艺.N,N′-dialkylalkyleneureas as a new muti-function solvent has been used widely.1,3-Dimethyl-2-Imidazolidinone（DMEU or DMI）,1,3-dimethyl-3,4,5,6-Tetrahydro-2（1H）-Pyrimidinone（DMPU） were obtained by cyclization and N-alkylide from the reaction of alkyldiamino with urea,the yield was 74.5% and 75.6% respectively.The objective compounds were characterized by GC and 1H-NMR.Furthermore,the art was tested successfully using 1 000 L reactor pilot.As a result,the efficiency general green synthesis of producing N,N′-dialkylalkyleneureas was established.

关 键 词：N N′-二烷撑基环脲 1 3-二甲基-2-咪唑酮 1 3-二甲基-2-嘧啶酮 环合反应 Eschweiler-Clark反应 

分 类 号：O622.6[理学—有机化学]