冷冻抽提相分离法制备聚乳酸多孔支架  

Fabrication of polylactide porous scaffolds by frozen extraction phase separation method

作　　者：焦简金[1] 丁晓红[1] 郑璇[1] 卢艺华[1] 刘榕芳[1] 肖秀峰[1] 

机构地区：[1]福建师范大学化学与材料学院,福建省高分子材料重点实验室,福建福州350007

出　　处：《功能材料》2011年第B06期567-572,共6页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(30600149,30970887);卫生部科学研究基金资助项目(WJK2008-02-037)

摘　　要：为了制备结构和性能满足骨组织工程支架要求的聚乳酸(PLA)多孔支架材料,采用冷冻抽提相分离法,以1,4-二氧六环和水为混合溶剂,聚乙二醇(PEG)为致孔剂,制得一系列PLA多孔支架,探讨了溶剂组成、PLA浓度、PEG添加量对PLA多孔支架结构和性能的影响,结果表明添加PEG有利于形成多孔三维支架,随着PEG含量的增加,孔隙率略有上升,抗压强度下降。随着PLA质量分数的增加,孔隙率明显下降,但抗压强度增大。当混合溶剂中水的含量不超过12%(质量分数),PLA浓度不超过12.5%(质量分数),PEG含量不超过20%(质量分数)时,可制得孔隙率和力学性能满足骨组织工程要求的多孔贯穿的支架材料。To prepare the polylactide（PLA） porous scaffolds whose structure and property could meet the needs of bone tissue engineering, a series of PLA porous scaffolds were prepared by frozon extraction phase separation method with using 1,4-dioxane and water as the blend solvent and poly（ethylene glycol）（PEG） as the porogen. The effect of solvent composition, PLA concentration and the amount of PEG on the structure and property were studied. The results showed that the addition of PEG was benificial for forming three-dimensionally por ous scaffolds. With the PEG amount increasing, the porosity slightly increased while the compressive strength improved. With the increasing of PLA mass fraction, the porosity decreased obviously while the compressive strength improved. When the mass fraction of water is no more than 12wt%-60wt%, the mass fraction of PI.A is no more than 12.5wt% and the mass fraction of PEG is no more than 20wt%, porous throughout materials with satisfying porosity and mechanical property could form.

关 键 词：聚乳酸 聚乙二醇 多孔支架 冷冻抽提相分离 

分 类 号：TB322[一般工业技术—材料科学与工程] TQ320.66[化学工程—合成树脂塑料工业]