盐酸羟甲唑啉喷雾剂对兔鼻腔黏膜刺激实验研究  

The study of oxymetazoline hydrochloride for rabbit nasal membrane spray stimulation test

作　　者：李鸣[1] 刘用国[1] 王江融[1] 林纾[2] 

机构地区：[1]福建省药品检验所,福州350001 [2]福建中医学院药学系,2006级福州350108

出　　处：《海峡药学》2011年第6期39-41,共3页Strait Pharmaceutical Journal

摘　　要：目的观察盐酸羟甲唑啉喷雾剂对家兔鼻腔喷雾给药的刺激反应,为临床用药安全提供依据。方法以家兔鼻腔连续喷雾给药7d,每天1次,每次每侧鼻腔4喷,设家兔给药组、辅料组和阴性对照组。结果盐酸羟甲唑啉喷雾剂给药组、辅料组及对照组家兔鼻腔黏膜组织经肉眼观察,未见充血、水肿、鼻孔周围分泌物、结痂等病变,刺激强度评价均为无刺激性。组织病理学镜检结果,给药组、辅料组对家兔鼻腔黏膜的刺激指数分别为0、0.5,刺激反应程度均为无刺激。结论盐酸羟甲唑啉喷雾剂对家兔鼻腔黏膜无刺激性。OBJECTIVE Observation of oxymetazoline hydrochloride nasal spray aerosol delivery in rabbits stimulated response.METHODS To rabbit nasal spray administration consecutive day,7 days a time,every time each side of the nasal spray 4,located in rabbits treated group,supplies,and negative control group.RESULTS Oxymetazoline hydrochloride spray treatment group,supplies,and control group rabbit nasal mucosa by the naked eye,no congestion,edema,secretions around the nose,scab and other diseases,are non-irritating stimulus intensity evaluation.Microscopic examination of tissue pathology,treatment group,auxiliary group of the rabbit nasal mucosa stimulation index were 0.05,stimulation levels were not stimulated.CONCLUSION Oxymetazoline hydrochloride spray irritant on rabbit nasal mucosa.

关 键 词：盐酸羟甲唑啉喷雾剂 鼻腔黏膜 刺激试验 

分 类 号：R969[医药卫生—药理学]