细菌性肺炎血清可溶性白细胞介素受体(sIL-1RⅠ、sIL-2R、sIL-4R)的测定及其临床意义  

Determination and clinical significance of serum soluble Interleukin receptor(sIL-1RⅠ、sIL-2R、sIL-4R)in patient with bacterial pneumonia

作　　者：江德富 王晔华 陈素萍 林竹娟 梁华斌 

机构地区：[1]浙江省温岭市第二人民医院儿科,台州317500 [2]浙江省温岭市第二人民医院检验科,台州317500

出　　处：《海峡药学》2011年第6期66-68,共3页Strait Pharmaceutical Journal

基　　金：温岭市科技局基金资助项目(No.2008-63)

摘　　要：目的探讨细菌性肺炎患儿血清水平可溶性白细胞介素受体(sIL-1RⅠ、sIL-2R、sIL-4R)的表达及其临床意义。方法以37例细菌性肺炎患儿(其中轻症26例,重症11例)和24例健康体检儿童(对照组)为研究对象,采用酶联免疫吸附试验法分别测定血清sIL-1RⅠ、sIL-2R、sIL-4R和IL-8水平。结果细菌性肺炎急性期患儿血清sIL-1RⅠ、sIL-2R、sIL-4R和IL-8水平显著性高于对照组(P<0.01)。恢复期血清sIL-1RⅠ、sIL-2R、sIL-4R和IL-8水平显著性低于急性期(P<0.01)。结论细菌性肺炎患儿急性期血清sIL-1R、sIL-2R、sIL-4R和IL-8的表达增加,而在恢复期下降。联合检测sIL-1RⅠ、sIL-2R、sIL-4R和IL-8水平变化有利于细菌性肺炎病情监测和疗效评价。OBJECTIVE To investigate the concentration of serum soluble Interleukin receptor（sIL-1RⅠ、sIL-2R、sIL-4R）protein in pediatric patients with bacterial pneumonia,and potential roles of them.METHODS All the patients were obtained during December 2008 to March 2009 including 37 cases of patients with bacterial pneumonia（26 of mild and 11of severe）,and were compared to 22 cases of volunteers.Concentrations of sIL-1RⅠ,sIL-2R and sIL-4R were detected by enzyme linked immunosorbent assay methods（ELASA）.And the Concentrations of IL-8 were also determined.RESULTS The concentrations of sIL-1RⅠ,sIL-2R,sIL-4R and IL-8 proteins were significantly higher from acute phase of bacterial pneumonia（39.62±11.91pg·mL-1,508±356 pg·mL-1,71.32±18.40 pg·mL-1,4.35±1.09ng·mL-1,respectively）than those in control group（13.04±2.48pg·mL-1,91±40 pg·mL-1,18.75±9.97pg·mL-1,1.48±0.54ng·mL-1,respectively）（all P0.01）.Data also showed that the concentrations of them were markedly lower at recovery stage（21.08±5.57pg·mL-1,174±58pg·mL-1,25.86±9.97 pg·mL-1,1.85±0.69ng·mL-1,respectively）than those at acute phase（all P0.01）.CONCLUSION Concentrations of sIL-1RⅠ,sIL-2R,sIL-4R and IL-8 were elevated at acut phase of bacterial pneumonia in pediatric patients.While they were decreased at convalescence stage.Our study indicated combination detection of serum sIL-1RⅠ,sIL-2R,sIL-4R and IL-8 levels are clinically useful in the management and evaluation of bacterial Pneumonia.

关 键 词：细菌性肺炎 可溶性受体 白细胞介素 酶联免疫吸附试验 

分 类 号：R969.4[医药卫生—药理学]