普罗帕酮对映体的化学拆分  

OPTICAL RESOLUTION AND DETERMINATION OF PROPAFENONE ENANTIOMERS

作　　者：张宜[1] 李高[2] 田世雄[2] 陈鹰[1] 

机构地区：[1]广州军区武汉总医院,武汉430070 [2]同济医科大学药学院,武汉430030

出　　处：《中国医药工业杂志》1999年第9期385-386,共2页Chinese Journal of Pharmaceuticals

摘　　要：使普罗帕酮外消旋体与（＋ ）或（－ ）－２，３－二对甲苯酰酒石酸作用，形成非对映异构体盐后分步结晶制备了（Ｒ）－和（Ｓ）－普罗帕酮，得率分别为６２％ 和６０％ 。并采用ＨＰＬＣ柱前手性衍生化法对产品进行了检测，其ｅ．ｅ．均大于９８％ 。Fractional crystallization was utilized to resolve the enantiomers of propafenone (1) as their diastereomeric salts with 2,3 di O,O′ p toluoyl tartaric acid (yield:(R) 1 62%;(S) 1 60%).The enantiomeric purities of the enantiomers were determined.The enantiomeric excess of (R) 1 as well as (S) 1 was over 98%.

关 键 词：普罗帕酮 手性衍生化法 非对映异构体盐 拆分 

分 类 号：TQ463.24[化学工程—制药化工] R972.2[医药卫生—药品]