HPLC-MS/MS测定比格犬血浆中喹硫平缓释片的药动学特性  

Pharmacokinetics of Extended-release Tablets of Quetiapine in Beagle Dogs by HPLC-MS/MS Method

作　　者：鲁涓[1] 蒋媛[1] 苏梦翔[1] 高义才 吴立明 狄斌[1] 冯芳[1] 

机构地区：[1]中国药科大学药物分析教研室,南京210009 [2]青岛黄海制药有限责任公司,青岛266101

出　　处：《药学与临床研究》2011年第3期279-281,共3页Pharmaceutical and Clinical Research

摘　　要：目的:建立比格犬血浆中喹硫平浓度测定的HPLC-MS/MS定量分析方法,研究喹硫平缓释片在犬体内的药动学特征。方法:采用6只健康成年比格犬随机分成2组,双交叉试验设计进行单剂量给药,并于相应的时间点采集血样,采用HPLC-MS/MS测定比格犬体内的血药浓度并计算主要药动学参数。结果:经统计分析,与普通参比制剂相比,受试缓释制剂的Cmax降低,tmax延迟,t1/2延长。结论:缓释片与普通片相比具有明显的缓释特征。Objective： To establish an HPLC-MS/MS method for the determination and pharmacokinetic study of quetiapine in Beagle dogs.Methods： Six beagle dogs were randomized into two groups.A two-way crossover study was adopted.Plasma samples were collected at different time points.Plasma concentration of quetiapine was determined by HPLC-MS/MS and pharmacokinetic parameters were calculated.Results： The results indicated that the tmax and t1/2 of extended-release tablets were longer than those of immediate tablets,and the Cmax of extended-release tablets was lower than that of immediate tablets.Conclusion： The test tablets have marked sustained release characters.

关 键 词：HPLC-MS/MS 喹硫平 血药浓度 比格犬 药代动力学 

分 类 号：R969.1[医药卫生—药理学]