光学异构20(R)-人参皂苷Rg_3微乳的相图研究  

Study on Ginsenoside Rg_3 Microemulsion by Ternary Phase Diagram

作　　者：刘志辉[1] 李琳[2] 周洪亮[3] 

机构地区：[1]江苏省中医院,南京210036 [2]滁州市中西医结合医院,滁州239000 [3]南京中医药大学,南京210029

出　　处：《药学与临床研究》2011年第3期284-286,共3页Pharmaceutical and Clinical Research

摘　　要：目的:筛选人参皂苷Rg3空白微乳处方组成。方法:通过滴定法绘制伪三元相图,以微乳区面积大小为指标,考察各系统的相图行为及各因素对微乳区形成的影响。结果:不同的表面活性剂、助表面活性剂、Km值、油相物质的种类、温度等对微乳形成均有较大影响。结论:Km=2,25℃时形成的曲拉通X-100/异丙醇/油酸乙酯/水微乳体系为最优的微乳体系。Objective： To screen for a ginsenoside Rg3 microemulsion formula.Methods： False ternary phase diagrams were drawn through titration,the size of microemulsion area was used as the index to study the phase diagrams formed by different systems and the factors affecting the formation of microemulsion area.Results： Surfactants,surface-active agents,Km,oils and temperature affect the formation of microemulsion.Conclusion： At Km 2 and 25 ℃,tritonX-100/isopropanol/ethyl oleate/water is the best microemulsion system.

关 键 词：人参皂苷RG3 微乳 伪三元相图 

分 类 号：R943[医药卫生—药剂学] R912[医药卫生—药学]