IVF失败者子宫内膜galectin-3表达及其容受性评估  

Expression of galectin-3 in windows phase evaluating the IVF-loser's endometrial receptivity

作　　者：赵世彬[1] 甄秀丽[1] 孙海茹[2] 张娜[1] 乜照燕[1] 张轶[1] 

机构地区：[1]河北医科大学第四医院,石家庄050011 [2]衡水哈励逊国际和平医院

出　　处：《山东医药》2011年第24期36-38,共3页Shandong Medical Journal

基　　金：河北省科学技术研究与发展计划项目(09276102D-8);河北省计生委科研项目(2010-A17)

摘　　要：目的以子宫内膜着床窗口期galectin-3表达评价体外受精—胚胎移植(IVF)失败者子宫内膜容受性。方法对IVF失败者11例的前一月经周期着床窗口期子宫内膜采用逆转录PCR技术检测子宫内膜galectin-3 mR-NA表达和免疫组化检测子宫内膜galectin-3蛋白表达及定位。结果IVF失败者子宫内膜着床窗口期galectin-3的表达明显低于妊娠组。结论IVF失败患者着床窗口期子宫内膜容受性欠佳,胚胎着床障碍是主要原因之一。Objective To evaluate in vitro fertilization（IVF）-loser＇s endometrial receptivity by investigating the expression of galectin-3 in windows phase.Methods The mRNA expression of galectin-3 was detected by RT-PCR method.Immunohistochemistry was used to detect the location and the expression of galectin-3 protein.Result Galectin-3 mRNA and protein expression in the non-pregnant group were obviously lower than those in the prengant group.Conclusion IVF-loser＇s endometrial receptivity is not good in implantation window,the embarrassment of embryo implantion is the foremost reason.

关 键 词：GALECTIN-3 受精 体外 子宫内膜容受性 

分 类 号：R711.6[医药卫生—妇产科学]