犬实验性急性心肌梗死的电子束CT检测  

Detection ofexperimentalacute myocardialinfarctionin dogs with electron beam CT

作　　者：张闽光[1] 宋志坚[2] 沈天真[1] 左焕琛[2] 冯晓源[1] 陈星荣[1] 

机构地区：[1]上海医科大学华山医院 [2]上海医科大学基础医学院

出　　处：《中华放射学杂志》1999年第10期672-674,共3页Chinese Journal of Radiology

摘　　要：目的　评价电子束ＣＴ（ＥＢＣＴ）增强容积扫描显示犬急性心肌梗死部位、形态、密度及大小的价值和限度。方法　结扎６ 只犬心冠状动脉左前降支及左旋支的分支，拟在左心室壁造成梗死区。结扎后１－５、６、１２、２０ 小时，分别作ＥＢＣＴ增强容积扫描，得到犬心脏ＣＴ断面图像。完成全部扫描后处死犬，采集心脏电子显微镜和光学显微镜标本作病理检查。仔细分析心肌缺血和梗死在ＥＢＣＴ图像上的形态学表现，测定并比较心肌缺血和梗死区与正常区的ＣＴ值及两者与左心室腔ＣＴ值的比值（Ｍ／Ｌ值）。结果　结扎后２０ 小时的心电图和病理均证实被结扎区出现典型的心肌梗死表现。在ＥＢＣＴ图像上急性心肌缺血和梗死的部位及形态显示清晰；缺血和梗死区的密度明显低于正常区，低密度区和正常心肌区的平均Ｍ／Ｌ值分别为１３－２％ 和３２－９％ ，差异有显著性意义（ Ｐ＜０－００１）。结论在恰当的检查条件下，ＥＢＣＴ可以对急性心肌缺血和梗死的部位、形态、密度与大小作出准确的评价。Objective Thevalue andlimitation of discoveringthe site,shape,density and size ofacute myocardialinfarction with enhanced volumescansofelectron beam computedtomography(EBCT)in experimental dogs were assessed- Methods The anterior descending and circumflex branches ofthe left coronary artery were ligated andinfarctioninthe wallofleftventricle wascreatedinsix dogs- Enhancementvolumescan was made with a EBCTscannerat1-5,6,12 ,and20 houraftertheligationand CTsectionalimagesofdogheartwere obtained- Afterfinishing the scanning,the dogs were then sacrificed,and the samples were sent for electron and optic microscopesfor pathologic examination- The morhpologic fingings of myocardial ischemia and infarction in CT images were carefully analysed- The CTnumbers and the ratios ofleft ventricular myocardial and luminal CT number(M/L) in the myocardialischemic andinfarcted areas and normalareas were calculated- Results The typical myocardialinfarctioninareasligated wereconfirmedby ECGand pathology20 hoursafterligation- Thesite and shape ofacute myocardialinfarction wereclearlyshown onthe EBCTimages- Thedensityoftheischemia and infarction area wassignificantlylowerthanthatofthe normal myocardium ( P<0-001)- M/Lsofthelow density areasand normal areas were 13-2% and 32-9% ,respectively- The difference was significant ( P< 0-001)- Conclusions With adequatescanningtechnique,thesite,shape,density and size ofacute myocardialischemia andinfarction can beaccuratelyassessed by EBCT-

关 键 词：心肌梗死 AMI CT 电子束 

分 类 号：R542.220.4[医药卫生—心血管疾病] R816.2[医药卫生—内科学]