开搏通温血停搏液对狗缺血心肌的保护作用  

Myocardial protective effects of captopril warm blood cardioplegia on ischemic myocardium in dogs

作　　者：秦斌[1] 胡爱民[1] 李玉华[1] 万士杰[1] 解士胜[1] 

机构地区：[1]解放军空军总医院心胸外科,北京100036

出　　处：《第四军医大学学报》1999年第9期767-768,共2页Journal of the Fourth Military Medical University

基　　金：人事部留学回国人员资助

摘　　要：目的：研究常温下含开搏通（ｃａｐｔｏｐｒｉｌ）的温血停搏液对缺血心肌保护作用． 方法：犬１６ 只随机分为对照组和实验组，体外循环开始后，结扎冠状动脉左前降支，分别灌注温血停搏液和含开搏通温血停搏液，并收集血流动力学和有关生化资料． 结果：对照组冠脉血管阻力（ Ｃ Ｖ Ｒ）大于实验组２ 倍（ Ｐ＜ ０．０１），二组间心肌组织 Ａ Ｔ Ｐ，腺苷和肌苷含量以及冠脉回流液中 Ｃ Ｐ Ｋ 和 Ｃ Ｐ Ｋ Ｍ Ｂ值均有显著性差异． 结论：含开搏通的温血停搏液可减小冠脉阻力，增加心肌血流量，保存心肌能量，减少心肌细胞破坏，有利于心肌功能恢复，其心肌保护作用优于单纯温血停搏液．AIM: To study the enhanced myocardial protective effects of warm blood cardioplegia (37℃) with captopril on the ischemic myocardium. METHODS: 16 dogs were divided into two groups, subjected to ischemic arrest at 37℃ for 30 minutes and followed by reperfusion of warm blood cardioplegia with or without captopril. RESULTS: The CVR in control group was two times higher than that in the captopril group. There was significant difference ( P< 0.05) in ATP, adenosine and inosine between the two groups. The amount of CPK and CPK MB leakage in captopril group was significantly smaller than that in the control group( P< 0 01). CONCLUSION: The warm blood cardioplegia with captopril markedly improves myocardial protection in ischemic myocardium.

关 键 词：开搏通 心肌缺血 温血停搏液 心肌保护 

分 类 号：R654.2[医药卫生—外科学]