慢性肾脏疾病中LDL-C两种测定方法的比较  

Comparison of two LDL-C Detecting Methods in Chronic Renal Diseases

作　　者：范瑾瑾[1] 高玲[1] 黄恩芳[1] 俞纯山[1] 

机构地区：[1]中山医科大学附属第一医院医学检验部,广州510080

出　　处：《陕西医学检验》1999年第4期22-23,共2页Shaanxi Journal of Medical Laboratory Sciences

摘　　要：目的：比较正常人及慢性肾脏疾病病人血清中两种测定LDL-C浓度方法的差异。方法：间接计算法利用Fredewald公式计算LDL－C的浓度，直接测定法即匀相分析法直接测得LDL－C浓度。结果：42例正常对照组两种方法测定结果无显著性差异（P＞0．1），r＝0．9794，表明正常人群中两种方法有良好的相关性。在37例慢性肾衰竭（CRF）的病人及25例肾综病人中，两种方法所得结果有显著性差异（P＜0．05），其中在CRF组中，r＝0．9314，而在肾综组中r＝0．8732，相关性均有所下降。结论：在慢性肾脏疾病中直接法测定LDL－C浓度由于不依赖其他脂质成分，是一个较间接计算法更为准确的方法。Objective: To compare two LDL-C measuring methods: uniforrnity medium assay and Fredewald formula calculating method. Methods Two different methods were both used to determme the serum LDL-C concentration in three differrent groups: normal control group (n = 42), nephrotic syndrome (NS) (n = 25 ) and chronic renal failure (CRF) (n = 37). Result Two methods showed no significant difference(P>0. 1) and a good correlation (r = 0. 979 4) in the control group. In the NS group and CRF group,there was a significant difference (P<0. 05) between the two methods and the correlation was lower (r = 0. 873 2 in NS, r = 0. 931 4 in CRF group). Conclusion The direct method appeared to be more accurate for detecting of LDL-C because it is not depended on other lipids components.

关 键 词：测定 慢性 肾脏疾病 LDL-C 

分 类 号：R692[医药卫生—泌尿科学]