吡柔比星在羧基离子注入氧化铟锡电极上的电化学还原及其测定  

Electrochemical Reduction and Voltammetric Determination of Pirarubicin at Carboxyl Ions Implantation-modified Indium Tin Oxide Electrode

作　　者：李硕琦[1] 杨玉飞[1] 杨少媛[1] 叶森云[1] 方华权[1] 胡劲波[2] 李启隆[1] 

机构地区：[1]北京师范大学化学学院,北京100875 [2]北京师范大学射线束技术与材料改性教育部重点实验室,北京100875

出　　处：《分析化学》2011年第7期990-993,共4页Chinese Journal of Analytical Chemistry

摘　　要：采用离子注入技术将羧基离子注入到氧化铟锡(ITO)表面,制备了羧基离子注入氧化铟锡电极(COOH/ITO)。电极表面羧基的引入用X射线光电子能谱(XPS)进行表征。此电极被应用到了吡柔比星的电化学行为的研究及其测定当中。在COOH/ITO电极上,吡柔比星在5 mmol/L磷酸盐缓冲溶液(pH 7.2)中,出现还原峰,峰电位为-0.57 V(vs.Ag/AgCl),峰电流与THP浓度在2.0×10-9～2.5×10-8 mol/L和1.4×10-7～2.8×10-6 mol/L呈线性关系,检出限为2×10-10 mol/L。循环伏安法研究表明,此体系属于吸附控制的不可逆过程,COOH/ITO对吡柔比星的电化学还原过程产生较大的促进作用。A carboxyl ion implantation-modified indium tin oxide（COOH/ITO） electrode was prepared,and the existence of carboxyl groups on the electrode was verified by X-ray photoelectron spectroscopy（XPS）.This modified electrode has been used for the determination of pirarubicin（THP） by cyclic voltammetry and differential pulse voltammetry.Compared to the bare ITO electrode,the modified electrode exhibited a marked enhancement in the current response.Liner calibration curves were obtained in the range from 6.0×10-10 to 2.5×10-8 mol/L and 1.4×10-7 mol/L to 2.8×10-6 mol/L with a detection limit of 2×10-10 mol/L.

关 键 词：吡柔比星 羧基离子注入 氧化铟锡 循环伏安 电化学 

分 类 号：O657.1[理学—分析化学]