55例真菌性败血症临床分析  

Clinical analysis of 55 patients with fungal septicemia

作　　者：肖秀红[1] 徐凤琴[1] 陈伯宁[1] 陈丽容[1] 

机构地区：[1]中山大学孙逸仙纪念医院医院感染管理办公室,广东广州510120

出　　处：《中华医院感染学杂志》2011年第13期2715-2716,共2页Chinese Journal of Nosocomiology

摘　　要：目的探讨真菌性败血症的发生特点、病原菌种类及防治策略。方法回顾性分析55例真菌性败血症患者的易感因素、病原学特点及治疗效果。结果 49例为医院感染,占89.09%,6例为社区获得性感染占10.91%,均有严重的基础疾病,主要致病菌为假丝酵母菌属占80.00%;32例好转,占58.18%,23例死亡或放弃治疗出院,占41.81%,应用广谱抗菌药物占85.45%,实施侵入性治疗占54.55%,化疗占36.36%,使用激素占29.09%,全胃肠外营养占25.45%,以上均是发生真菌性败血症的危险因素。结论对高危患者应重视病原学检测,尽可能早期诊断、祛除易感因素、合理选用抗真菌药物有助于降低病死率。OBJECTIVE To study the clinical characeristics, fungal species, therapy and prevention of fungal septicemia. METHODS A retrospective analysis of predisposing factors, distribution of fungi, treatment and outcome of 55 patients with fungal septicemia was performed. RESULTS Except 6 patients with fungemia occurred outside hospital,other 49 cases （89.09%）were criterial for nosocomial fungemia. All patients had severe diseases and 49 nosoeomial fungemia cases had various risk factors of fungemia. Candida species were the most frequently isolated strains. 32 patients （58.18%） took a favorable turn and 23 （41.81%） died or discharged because of giving up remedy. Underlying severe diseases （100. 00%）, prior broad spectrum an,imicrobial therapy （85.45 %）, invasive ＂therapy （54.55 %）, cytotoxic/steroids chemotherapy （36.36 %/29.09 %）, and parenteral nutrition （25.45%）were the risk factors. CONCLUSION Removing predisposing factors, isolation of pathogens, early diagnosis, and correct choice of antifungal agents in high risk patients are important measurements to reduce

关 键 词：真菌性败血症 早期诊断 治疗策略 

分 类 号：R379[医药卫生—病原生物学]